CNS infections Flashcards
What happens grossly with pyogenic meningitis?
a thick layer of suppurative exudate which covers the meninges over the surfave of the brain esp. in basal and convex surfaces
What is seen micrsocopically in pyogenic meningitis?
neutrophils in the subarachnoid space
When is viral meningitis commonly seen?
late summer/autumn
What commonly causes viral meningitis?
enteroviruses eg ECHO
What investigations are done with viral meningitis?
viral stool culture; throat swab and CSF PCR
What is the treatment for viral meningitis?
supportive as self-limiting
What are the clinical features of encephalitis?
insidious onset; sometimes sudden; meningismus; stupor, coma; seizures; confusion; psychosis; speech and memory symptoms
What are the investigations for encephalitis?
LP; EEG and MRI
What treatment should be started immediately with encephalitiy?
aciclovir
What are the most common causes of bacterial meningitis in neonates?
listeria; group B strep; e.coli
What are the most common causes of bacterial meningitis in children?
H.influenza
What are the most common causes of bacterial meningitis in ages 10-21?
neisseria meningitidis
What are the most common causes of bacterial meningitis over 21s?
strep. pneumo > neisseria meningitidis
What are the most common causes of bacterial meningitis in over 65s?
strep. pneumo > listeria
What bugs do patients wti hdecreased cell mediated immunity tend to get?
listeria monocytogenes
What bugs do neurosurgery or head trauma pts get?
staph; gram negatvie bacilli; s.epidermidis
What bug do patients with cribiform plate #s get?
strep. pnuemo
What bugs do patients with a CSF shunt get?
s. epidermidis; s.aureus; aerobic GNR; propionibacterium acnes
What CNs are particularly vulnerable in purulent meningitis?
III and VI