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Neurology - professional - batt > Chronic Pain > Flashcards

Chronic Pain Flashcards

1
Q

What is chronic pain?

A

pain beyond expected period of healing and which no longer serves a useful purpose- secondary to physiological changes in signalling and dection of pain

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2
Q

What is neuropathic pain?

A

an inappropriate response caused by a dysfunction in the nervous system

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3
Q

What are common causes of neuropathic pain?

A

shingles; surgery; trauma; diabetic neuropathy; amputation

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4
Q

What is the efficacy of NSAIDs?

A

nociceptive pain

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5
Q

What is the MOA of NSAIDs?

A

inhibition of COx and prostaglandin synthesis

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6
Q

What are the SE of NSAIDs?

A

GI irritation; renal toxicitiy; potential drug-drug interactions; CVS SE

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7
Q

What is the efficacy of paracetamol?

A

analgesic and antipyretic- no anti-inflam

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8
Q

What is the MOA of paracetamol?

A

inhibition of central prostaglandin synthesis but not fully understoof

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9
Q

Waht is the efficacy of opiod analgesics?

A

nocicepitve pain; less effective in chronic states; partially effective in neuropathic pain

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10
Q

What is the MOA of opioids?

A

activate endogenous analgesic system

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11
Q

What are the SE of opioids?

A

N and V; constipation; dizziness/vertigo; somnolence; dry skin, pruritius

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12
Q

What is the efficacy of tricyclics?

A

neuropathic pain; CRPS; tension headache

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13
Q

What is the MOA of TCAs?

A

inhibition of neuronal reuptake of noradrenaline and serotonin

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14
Q

What are the SE of TCAs?

A

constipation; dry mouth; somnolence; abnormalities in HR or rhythm; insomnia; increased appetite

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15
Q

What is the efficacy of SSRIs and SNRIs?

A

neuropathic pain

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16
Q

What is the MOA of SSRIs and SNRIs?

A

inhibiti reuptake of noradrenaline or serotonin or both; provide analgesia by intesifying descending inhibition

17
Q

Waht are the SEs of SSRIs and SNRIs?

A

N and V; constipation; somnolence; dry mouth; increased sweating and loss of appetite

18
Q

What is the MOA of gabapentin?

A

binds to presynaptic voltage calcium channels

19
Q

What is the MOA of pregabalin?

A

interacts with special N-type calcium channels

20
Q

What is the MOA of carbamazepin?

A

blocks sodium and clacium channels

21
Q

What are the SE of anticonvulsants?

A

sedation; dizziness; ataxia; peripheral oedema; nausea and weight gain

Neurology - professional - batt (40 decks)

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