Clearance Flashcards by Gabby Leighow | Brainscape

Q

Why is it important to understand clearance?

A

It shows how well the kidney is filtering/working

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Q

Are chronic kidney diseases curable?

A

No

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Q

What can be used to measure renal plasma flow?

A

Para-aminohippurate (PAH)

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Q

How much PAH is eliminated in urine?

A

90%

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Q

How can you calculate renal blood flow?

A

From renal plasma flow and hematocrit

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Q

What could compromise renal drug excretion?

A

Glomerular filtration and active secretion

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Q

What can you calculate from clearance?

A

GFR
Secretion amt
Reabsorption amt

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Q

What are some secreted drugs in the kidney?

A

Penicillin
Morphine
Furosemide
Atropine
Probenicid

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Q

The clearance of PAH must be…

A

Greater the clearance of inulin

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Q

What are some absorbed substances?

A

Amino acids
Glucose
Bicarb

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Q

What is the clearance of glucose?

A

0

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Q

When does clearance of glucose exceed 0?

A

When plasma glucose concentration is above normal levels and surpasses PT glucose transport maximum

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