Chp 25 PP Flashcards

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1
Q

urinary system maintains what

A

fluid homeostasis

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2
Q

urinary system regulates what

A

regulation of volume and composition by eliminating certain wastes while conserving needed materials

regulation of blood pH

regulation of hydrostatic pressure of blood and, indirectly, of other body fluids

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3
Q

gluconeogenesis means

A

create new sugar

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4
Q

urinary system helps synthesize

A

calcitriol (active form of Vitamin D)

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5
Q

urinary system secretes

A

erythropoietin

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6
Q

what happens to the urinary system during starvation

A

performs gluconeogenesis

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7
Q

what does the urinary system deaminate

A

certain amino acids to eliminate ammonia

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8
Q

smallest fuctional unit of a kidney

A

hron

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9
Q

what are the three physiological processes of the nephron

A

1) filtration,

2) reabsorption 3) secretion

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10
Q

where are the kidneys located in the body

A

Retroperitoneal

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11
Q

nephrons are made up of what parts

A

renal corpuscle- where the glomerulus starts. Specifically afferent and efferent vessels.

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12
Q

nephrons are made up of what parts

A

renal corpuscle- where the glomerulus starts. Specifically afferent and efferent vessels.

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13
Q

why is the glomerulus pressurized

A

is meant to help filter things is pressurized because the afferent arterial is larger and efferent vessel is smaller

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14
Q

where is the glomerulus located

A

renal corpuscle

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15
Q

In the kidney the filtrate is carried by

A

the collecting duct system through the medulla

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16
Q

The urine is collected in the kidney where

A

at the papillae into the minor and major calyxes

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17
Q

Renal corpuscle

is what

A

site of plasma filtration

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18
Q

renal corpuscle is made up of

A

2 components

  • glomerulus
  • glomerular (Bowman’s) capsule
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19
Q

glomerulus is made up of

A

tuft of capillary loops

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20
Q

glomerulus is fed by

A

afferent arteriole

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21
Q

glomerulus is drained by

A

drained by efferent arteriole

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22
Q

glomerular (Bowman’s) capsule

is?

A

double walled cup lined by simple squamous epithelium

outer wall (parietal layer) separated from inner wall (visceral layer = podocytes) by capsular (Bowman’s) space

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23
Q

what happens as blood flow flows through the capillary tuft?

What does not cross?

A

filtration occurs

  • water and most dissolved molecules pass into capsular space
  • large proteins and formed elements in the blood do not cross
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24
Q

where filtered fluid passes from capsule in the nephron

A

renal tubule

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25
Q

pathway of fluid in the nephron

A

proximal convoluted tubule (PCT)

loop of Henle (nephron loop)

distal convoluted tubule (DCT)

short connecting tubules

collecting ducts

merge to papillary duct

  • then to minor calyx
  • 30 pap ducts/papillae
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26
Q

two different types of nephrons

A

Cortical vs. juxtamedullary nephrons

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27
Q

location of a nephron is related to

A

the length of loop of the nephron

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28
Q

15-20% of the nephrons have longer loops and increased

A

involvement in the reabsorption of water

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29
Q

Histology of the glomerular filtration membrane

A
  • Three components to the filter

- From inside to out, the layers prevent movement of progressively smaller particles

30
Q

what happens if you have a proteins, R/WBC, glucose inside of the glomerulus causing what

A

bursting kidneys, kidney failure

31
Q

Endothelium of glomerulus

A

Single layer of capillary endothelium with fenestrations

Prevents RBC passage; WBCs use diapedesis to get out

32
Q

Basement membrane of glomerulus

A

Between endothelium and visceral layer of glom. capsule

Prevents passage of large protein molecules

33
Q

Filtration slits in podocytes in glomerulus

A

Podocytes
specialized epithelium of visceral layer
footlike extensions with filtration slits between extensions

Restricts passage of medium-sized proteins

34
Q

Histology of Filtration Membrane of glomerulus

A

1) Endothelium (pores inside)
2) Basement membrane
3) Filtration slits in podocytes

35
Q

Renal Blood supply flow of kidneys

A

1) Renal arteries
2) Segmental arteries
3) Interlobar arteries - through columns
4) Arcuate arteries
5) Interlobular arteries

36
Q

vessel that long networks from the efferent arteriole around the Loop (juxtamedullary nephrons)

A

Vasa recta

37
Q

Peritubular capillaries of kidneys are known as

A

Vasa recta

38
Q

Renal veins - exit where

A

hilus

39
Q

Renin-Angiotensin System is what kind of apparatus

A

Juxtaglomerular apparatus (JGA)

40
Q

Juxtaglomerular apparatus (JGA) is found where

A

Distal tubule contacts afferent arteriole at renal corpuscle

41
Q

Angiotensinogenase is

A

renin

an enzyme

42
Q

Angiotensinogenase is released when

A

only three times

1) Blood pressure down
2) blood volume down
3) sympathetic nervous system on

43
Q

what is released during a hemmorrage or dehydration

A

renin

Angiotensinogenase

44
Q

Juxtaglomerular (JG) cells

A

modified smooth muscle cells in afferent arteriole wall detect changes in blood pressure (a stretch reflex)

Secrete enzyme renin to trigger Renin-Angiotensin System if blood pressure falls

45
Q

Renin-Angiotensin System is secreted by

A

kidney

46
Q

Angiotensinogenase when released creates

A
angiotensin I (inactive form)
in lungs ACE (Angiotensin Converting Enzyme)  is released 
then you release angiotensin II active form (very powerful vasoconstrictor)
47
Q

why would someone be prescribed ACE inhibitor

A

to combat hypertension

48
Q

what is Distal tubule contacts afferent arteriole at renal corpuscle

A

Juxtaglomerular apparatus (JGA)

49
Q

what does the Juxtaglomerular apparatus (JGA)

do

A

cells that detect pressure in the glomerulus

50
Q
Juxtaglomerular apparatus (JGA)
tells the kidneys to do what when there is more pressure coming into the glomerulus
A

secrete more water

51
Q

two cells at the efferent arterials Juxtaglomerular apparatus (JGA)

A

macula densa

and JG

52
Q

cells work together to regulate blood pressure and blood volume

A

Both JG and MD

53
Q

What does the D in VItamin D stand for

A

dicholecalciferol

54
Q

dicholecalciferol is

A

vitamin d

55
Q

kidneys can activate what in Vitamin D

A

calciferol

56
Q

stimulate JG cells to

A

release renin if filtrate is too dilute, indicating insufficient filtration and/or low blood pressure/low blood volume

57
Q

Macula Densa (MD) cells

A

special cells in the wall of the distal tubule in this area monitor the osmotic potential in the filtrate in the distal tubule

58
Q

Juxtaglomerular (JG) cells are

A

modified smooth muscle cells in afferent arteriole wall detect changes in blood pressure (a stretch reflex)

59
Q

Juxtaglomerular (JG) cells secrete

A

enzyme renin to trigger Renin-Angiotensin System if blood pressure falls

60
Q

diabetes insipidis is

A

clear.
-lack of ADH (Anti diuretic hormone)
-happens if you are an alcoholic
not reabsorbing anything, causes you to be dehydrated
-Can create more ADH but can hurt the kidneys permanently

61
Q

What is the role of sympathetic stimulation on renal blood flow?

A

In “Fight or Flight” or muscular exertion:

  • decrease renal arterial flow
  • decrease urine production
  • maintain blood volume
  • increase systemic blood pressure
62
Q

Glomerular filtration is the

A

first step in urine formation

63
Q

Glomerular filtration

A

-forcing of fluids and dissolved solutes through membrane by hydrostatic pressure
-same process as in systemic capillaries
results in a filtrate
180 L/day, about 60 times plasma volume

64
Q

lack of ADH causes

A

diabetes insipidis

65
Q

acidosis

A

increased H ions

66
Q

Cells of the renal tubule can elevate blood pH in 3 ways:

A

Secrete H+ ions into the filtrate
Reabsorb filtered HCO3-
Produce more HCO3

67
Q

is a toxic waste absorbed from bacterial metabolism in the large intestine and ammonia is generated from the deamination of amino acids in the liver

A

Ammonia

68
Q

Liver converts ammonia to

A

urea

69
Q

cells can also deaminate certain amino acids and secrete additional NH4+ with a Na+/NH4+ antiporter when blood pH becomes acidic

A

PCT (proximal convoluted tubule)

70
Q

PCT (proximal convoluted tubule) reabsorbs

A

nutrients, electrolytes, and water