Chp 23 PP Flashcards
Digestive Processes
1) Ingestion
2) Movement of food
3) Digestion
- Mechanical digestion
- Chemical digestion
4) Absorption
5) Defecation
Digestive organs divided into 2 main groups
1) GI (alimentary) tract
2) Accessory structures
- cheeks, teeth, tongue, salivary glands
- liver, gallbladder, pancreas
3 pairs salivary glands
- Parotid glands
- Submandibular glands
- Sublingual glands
digests carbohydrates
salivary amylase
Functions of Saliva
- Water dissolves food for taste and digestion
- Mucous moistens and lubricates food
- Mucous lubricates oral surfaces for smooth actions in swallowing and speech
- Cl- ions activate amylase
- HCO3- and PO4- ions buffer bacterial acids
- IgA, lysozymes, cyanide, defensins: protect against microorganisms
what stimulates salivation
Food (mechanically, chemically)
behavioral – memories from cortex
starts digestion
continues after ingestion is complete
irritating foods or nausea
Functions of Saliva
Water dissolves food for taste and digestion
Mucous moistens and lubricates food
Mucous lubricates oral surfaces for smooth actions in swallowing and speech
Cl- ions activate amylase
HCO3- and PO4- ions buffer bacterial acids
IgA, lysozymes, cyanide, defensins: protect against microorganisms
Secretion of Saliva - 1-1.5 L l day is under what control
Primarily under nervous control
if your parasympathetic nervous system is turned on what happens to the salivary secretions
normal salivary secretions
saliva swallowed
most reabsorbed
if your sympathetic nervous system is turned on what happens to salivary glands
reduced flow (dry mouth)
mastication
Chewing
Food mixed with saliva
Shaped into a
bolus
salivary amylase breaks down and converts polysaccharides (starches
to disaccharides (maltose) and monosaccharides (glucose) [no enzymatic action with cellulose which is also a polymer of glucose]
how is bolus moved to the stomach
through three phases…
buccal
pharyngeal
Esophageal
facilitated by saliva
what parts of the body are used to move bolus from the mouth to stomach
mouth
pharynx
esophagus
buccal phase is
Voluntary
Moves bolus to oropharynx
Pharyngeal phase
-Involuntary
Receptors in oropharynx stimulate medulla and pons to:
1) Block mouth with tongue
2) Block nasopharynx with soft palate
3) Raise larynx to seal epiglottis, blocking airways
4) Relax upper esophageal sphincter
-Bolus is moved through pharynx into esophagus
Esophageal stage
- Upper esophageal sphincter closes
- Gastroesopaheal sphincter opens
- Esophagus controls involuntary peristaltic movement
- Epiglottis reopens
- Bolus moves from esophagus to stomach
Peristalsis
Involuntary, rhythmic contraction of muscularis
Controlled by medullary centers
A movement activity: inner circular layer of smooth muscle contracts behind bolus to push it forward; outer longitudinal muscle contracts to pull esophagus wall up
Physiology of Esophagus
Upper esophageal sphincter
Peristalsis
Lower esophageal (“cardiac”) sphincter
Sharp transition from nonkeratinized stratified squamous epithelium to simple columnar epithilium
Esophageal epithelium resistant to abrasion but not to acid and proteolytic enzyme attack – acid reflux disease
Physiology of digestion - Mechanical digestion
- peristaltic movement (mixing waves) back and forth between body and pylorus
- 3 muscle layers: longitudinal, circular, and oblique
- chyme
Physiology of digestion - Chemical digestion
parietal cells secrete intrinsic factor for B12 absorption
parietal cells secrete HCl by active transport
chief cells secrete pepsinogen (inactive precursor)
parietal cells secrete HCl by active transport
- kills microbes, denatures proteins
- causes some acid hydrolysis of food molecules
- stimulates secretion of hormones for bile & pancreatic juice flow
chief cells secrete pepsinogen (inactive precurso)
- activated to pepsin by HCl acid and by other pepsins
- only an effective protease at acid pH
- cleaves proteins into smaller peptides
Stomach: Mucosa contains
Gastric gland chief cells
Simple columnar epithelium with goblet cells and gastric pits
Simple columnar epithelium with goblet cells and gastric pits
Goblet & gastric pit mucous cells secrete mucin
Gastric gland G cells (enteroendocrine)
Gastric gland chief cells secrete
Secrete pepsinogen (inactive precursor)
Secrete rennin in neonates
Secrete gastric lipase in neonates
chief cells Secrete pepsinogen (inactive precursor)
activated to pepsin by HCl acid and by other activated pepsin enzymes
only an effective protease at acid pH
cleaves proteins into smaller peptides
chief cells Secrete rennin in neonates
curdles milk to increase time for gastric processing
chief cells Secrete gastric lipase in neonates
splits short chain triglycerides common in milk
limited role in digestion since it works best at pH 5-6
Simple columnar epithelium with goblet cells and gastric pits
Secretes
2-3 L l day
Gastric gland parietal cells
Secrete
intrinsic factor for B12 absorption
HCl by active transport
- kills microbes, denatures proteins
- causes some acid hydrolysis of food molecules
- stimulates secretion of hormones for bile & pancreatic juice flow
Goblet & gastric pit mucous cells secrete
mucin
1-3 mm mucus layer in the stomach prevents self-digestion
Gastric gland G cells (enteroendocrine)
Secrete
gastrin, histamine, serotonin, somatostatin
Absorption
of mucosa
Impermeable to diffusion of most molecules into the bloodstream
Absorbs a few lipid soluble compounds:
certain drugs (e,g., aspirin)
alcohol
Physiology of the liver - processes vital to life
- Storage – oil-soluble vitamins, iron, other nutrients and minerals
- Phagocytosis
- Removal of dietary toxins, hormones, drugs
- –detoxify or store or secrete compounds into bile
- –metabolize thyroid, steroid hormones
- Synthesis of bile salts
- Excretion of bile - bilirubin
- Activation of Vitamin D (?)
Pathologies of the liver –
hepatitis (viral, toxic), cirrhosis, cancer
Gall Bladder shape
Pear-shaped sac, 7-10 cm long
Gall Bladder physiology
- stores and concentrates bile between meals
- CCK stimulates bile release for fatty meals
- when the small intestine is empty, the hepatopancreatic sphincter closes, forcing bile into the gallbladder for storage
cirrhosis
harden liver
Summary: Digestive Hormones
enteroendocrines Gastrin Gastric Inhibitory Peptide Secretin Cholecystokinin
Small Intestine: Segmentation
primary action of small intestine when food is present
a form of mechanical digestion
a mixing activity
alternate contraction, relaxation of antagonistic smooth (circular and longitudinal) muscle segments in the intestine
controlled by the autonomic nervous system
Small Intestine: Peristalsis
as absorption continues, distension decreases and true peristalsis starts
a movement which propels chyme onward
these weak movements which occur only after most nutrients have been absorbed
only fat soluble vitamins
ADEK
vitamins that can be toxic to the liver
ADEK
Stomach Regulated by combination of
neuronal and hormonal factors
3 phases of stomach
Cephalic
Gastric
Intestinal