Chapter 47: Development Flashcards
model organisms
organisms used for developmental research; easily available or bred
fertilization
union of sperm and egg
vitelline layer
extracellular matrix of unfertilized egg
jelly coat
coat of unfertilized egg that protects egg and attracts sperm
acrosomal reaction
reaction triggered by contact of egg with sperm
acrosome
vesicle at sperm tip with hydrolytic enzymes break down jelly
acrosomal process
structure w/ proteins that bind receptors on eggs
depolarization
fusion leads to change in membrane potential
polyspermy
multiple sperm fertilizing an egg; blocked by depolarization and fertilization envelope
cortical reaction
initiated by fusion of egg and sperm; vesicles in cortex fuse with plasma membrane, leads to fertilization envelope
fertilization envelope
slower response to block polyspermy; separates vitelline layer from plasma membrane and breaks up receptors so more sperm don’t bind
activation of the egg
follows cortical reaction; increased respiration and protein synthesis, sperm nucleus fuses with egg nucleus
cleavage
earliest division, rapid; cell division without growth
blastomeres
individual cells formed by cleavage
blastula
hollow ball of cells with a blastocoel
blastocoel
internal cavity of blastomeres
cytoplasmic determinants
proteins, mRNA, etc. in specific places that code for body polarity
yolk
stored nutrients; help determine first cleavage
vegetal pole
pole in which yolk is concentrated
animal pole
pole opposite the vegetal pole
animal-vegetal axis
anterior-posterior axis
light gray crescent
area opposite sperm entry; sets polarity at fertilization
shape of blastula
influenced by presence of yolk; 8 cells, unequal, offset by yolk
gastrulation
the ball of cells turns into a structure with tissue layers and a gut
gastrula
early gut
3 germ layers
ectoderm, endoderm, mesoderm
vegetal plate
future endoderm; invaginates and becomes archenteron
archenteron
open cavity in the gastrula; blastopore is the opening and future anus in deuterostomes
ectoderm
skin, nervous system, and other
mesoderm
skeleton, muscles, circulatory system, excretory system, lining of body cavity, and others
endoderm
lining of digestive tract, respiratory system, and others
early organogenesis
cells differentiate to form organs; notochord, neural plate, neural tube, neural crest cells, somites
cell differentiation and morphogenesis
continuation of organogenesis that leads to adult organs
blastoderm
a disk that forms as two layers of cells on a large yolk
hypoblast
cell layer of blastoderm on yolk
epiblast
cell layer of blastoderm on top
primitive streak
gastrulation by migration of epiblast cells toward yolk
extraembryonic membranes
chorion, amnion, yolk sacs, allantois
chorion
extraembryonic membrane that functions in gas exchange
amnion
extraembryonic membrane that encloses embryo in fluid
yolk sac
extraembryonic membrane that surrounds yolk
allantois
extraembryonic membrane that sequesters waste products
blastocyst
mammalian blastula consists of trophoblast and inner mass cells
trophoblast
outer epithelium that initiates implantation; secretes enzymes to break down endometrium;
inner mass cells
part that will become the embryo; form epiblast and hypoblast
placenta
derived from trophoblast, mesoderm from the epiblast, and endometrial tissue; forms from embryonic and maternal tissue to exchange, nutrients, gases, wastes, etc.
fetus
late embryo, after about 8 weeks in humans
animals cells change shape
use of cytoskeleton; microtubules elongate and microfilaments narrow the apex
cell adhesion molecules
used by cells to form stable tissues; glycoproteins on cell surfaces
migration of cells
mediated by extracellular matrix
cells differentiate
division of cells into different functions with specific body axes, gene expression, etc.; begins with cytoplasmic determinants
induction
changes in gene expression based upon cell-cell interaction; pattern formation and positional information
fate map
map of cell differentiation
developmental potential
ability of a cell to become different types of cells; lost as cell lines develop
totipotent
ability of a cell to differentiate into any function
limb buds
beginning of limbs, covered in a layer of ectoderm
apical ectodermal ridge (AER)
tip of bud; secretes growth factor that extends limb bud
zone of polarizing activity (ZPA)
a group of cells in the posterior limb bud that controls the anteroposterior (AP) patterning of the limb