Chapter 44 :: Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) Flashcards
1
Q
SCORTEN
A
Age > 40 yr: 1
Heart rate > 120 beats/min: 1
Cancer or hematologic malignancy: 1
Body surface area involved >10%: 1
Serum urea level > 10 mM: 1
Serum bicarbonate level <0mmol/L: 1
Serum glucose level > 14 mM: 1
2
Q
Scorten Mortality Rate
A
0–1: 3.2%
2: 12.1%
3: 35.8%
4: 58.3%
5: 90%
3
Q
Drugs with a high risk to induce SJS/TEN
A
Allopurinol
Lamotrigine
Cotrimoxazole (and other antiinfective sulfonamides
and sulfasalazine) Carbamazepine
Nevirapine
NSAIDs (oxicam type, eg, meloxicam)
Phenobarbital
Phenytoin
4
Q
There is no laboratory test to support the diagnosis of EN
A
5
Q
During the acute phase, the most common complication of EN
A
Sepsis
6
Q
EN induced by carbamazepine in persons of Southeast Asian ancestry
A
HLA-B ∗ 1502
