Chapter 111 :: Basal Cell Carcinoma and Basal Cell Nevus Syndrome

Question 1

most common cancers in humans

have mutations activating the Hedgehog signaling pathway

Answer 1

Basal cell carcinomas (BCCs)

Question 2

most common clinical subtype of BCC

appears as a translucent papule or nodule.

There are usually telangiectasias and often a rolled border

Answer 2

NODULAR BASAL CELL CARCINOMA

Question 3

Well-demarcated, erythematous patch

Buds of malignant cells

extending into the dermis from the basal layer of the epidermis. Minimal dermal involvement.

Answer 3

Superficial BCC

Question 4

preferred treatment for recurrent BCC and for any BCC that occurs at a site where tissue conservation is desired

Answer 4

MOHS MICROGRAPHIC SURGERY

Question 5

cure rates for standard excisional surgery are inferior to those for MMS in cases of primary morpheaform BCCs, recurrent BCCs, and tumors located in high-risk anatomic sites

Answer 5

Vismodegib

Question 6

approved by the FDA in 2012 for patients with locally advanced or metastatic BCC