Chapter 114 :: Paget’s Disease

Question 1

malignant Paget cells arise from an underlying breast adenocarcinoma and directly extend into the epidermis via the lactiferous ducts and ductules (epidermotropism)

Answer 1

epidermotropic theory

Question 2

sensitive markers for both MPD and EMPD

stain Paget cells but do not typically react with epidermal or mucosal keratinocytes, helping to distinguish MPD and EMPD from pagetoid squamous cell carcinoma

Answer 2

cytokeratin 7 (CK7) and anticytokeratin (CAM 5.2)

Question 3

generally negative in primary EMPD but may be expressed in cases of secondary EMPD with an associated underlying colorectal adenocarcinoma

Answer 3

MUC2 expression

Question 4

In patients with MPD with negative mammography and without a palpable breast mass

Answer 4

mastectomy