Chapter 19 :: Carcinogenesis and Skin

Question 1

typically require that only one allele undergo activation via mutation

Answer 1

oncogenes

Question 2

nevoid BCC syndrome (NBCCS) is caused by germline mutations disrupting the

Answer 2

PTCH1 gene

Question 3

a skin fragility disorder caused by loss-of-function mutations in COL7A1, which results in subepidermal blistering, nonhealing wounds, and a high predisposition to SCC

Answer 3

Recessive dystrophic epidermolysis bullosa

Question 4

8-Methoxypsoralen

Answer 4

SCC, BCC, melanoma

Question 5

sporadic BCCs

Answer 5

PTCH1 or SMO mutations