Chapter 117 :: Histiocytosis

Question 1

Translucent, roseyellowish, crusted papules or papulovesicles, eczematous lesions, hemorrhagic papules and nodules, petechiae, noduloulcerative mucosal lesions, and nail involvement

Answer 1

Langerhans cell histiocytosis

Question 2

Solitary as well as multiple (oligolesional) papules or nodules—early lesions show a reddish-brown color; mature lesions have a reddish-yellow appearance

Answer 2

Juvenile xanthogranuloma

Question 3

Multiple asymptomatic and symmetrically distributed brownish erythematous papules, particularly involving the axial regions such as the trunk, face, and proximal extremities, frequently flares

Answer 3

Generalized eruptive histiocytoma

Question 4

Small, yellow-red to brown papules and nodules that are discrete and are disseminated with a predilection for the flexural and intertriginous areas, as well as for mucous membranes

Slowly progressing disease

Answer 4

Xanthoma disseminatum

Question 5

Xanthelasma and xanthoma are present in one-sixth of cases; long bone and other extracutaneous involvement

Answer 5

Erdheim-Chester disease

Question 6

Generalized, discrete yellow to red-brown papules and nodules measuring a few centimeters in size with prominent facial involvement

Answer 6

Progressive nodular histiocytosis