Chapter 15 :: Epidermal and Dermal Adhesion

Question 1

primarily responsible for epidermal adhesion

Answer 1

Desmosomes

Question 2

target of pathogenic autoantibodies in mucosal and mucocutaneous pemphigus vulgaris and paraneoplastic pemphigus

Answer 2

Desmoglein 3

Question 3

Ablation of BP230 is associated with

Answer 3

epidermolysis bullosa simplex

Question 4

Anchoring fibril proteins

Answer 4

Collagen VII

Question 5

Functional deficiency of collagen VII as a result of mutations in the COL7A1 gene leads to traumainduced separation of the epidermis and the dermis

Answer 5

dystrophic epidermolysis bullosa