Chapter 24 :: Allergic Contact Dermatitis Flashcards
Allergic contact dermatitis (ACD)
s a cell-mediated (type IV), delayed type, hypersensitivity reaction
most prevalent contact allergens in the general populations
nickel
Pigmented ACD
Riehl melanosis
one of the most potent sensitizers known and is widely used as an ingredient in hair dyes
para-phenylenediamine (PPD)
nail lacquer
tosylamide formaldehyde resin
major constituent of many sunscreens, is also a common ingredient in many lip products
Benzophenone-3 (oxybenzone)
most common class of allergens to cause ACD of the feet are rubber-related chemicals
mercaptobenzothiazole
potential cross-reactors with balsam of Peru
Tomatoes, citrus peel/zest, chocolate, ice cream, wine, beer, dark-colored sodas, and spices such as cinnamon, cloves, curry, and vanilla
testing to liquid products with irritant potential
semiopen patch test
represents a weak nonvesicular reaction but with palpable erythema
+
represents a strong (edematous or vesicular) reaction
++
represents an extreme (bullous or ulcerative) reaction
+++
erythematous reactions limited to the site of application of the chemical, with sharp, well-delineated margins; discretely scaly (may look “chapped”) and usually not edematous
irritant patch test reaction