Chapter 183 :: Principles of Topical Therapy

Question 1

rate-limiting barrier to percutaneous drug delivery

Answer 1

Stratum corneum

Question 2

most abundant composition of stratum corneum

Answer 2

acylceramides

Question 3

Low Relative percutaneous absorption of hydrocortisone

Answer 3

Ankle

Question 4

Wound cleansers, absorptive agents; applied on decubiti or leg ulcers

Answer 4

Poultice or Cataplasm

Question 5

Prevent evaporation of moisture from the skin

ideal for diaper rash, incontinence, bedsores, colostomy sites

Answer 5

Hydrocarbon base Ointment

Question 6

Most commonly used to deliver a drug

Glycerin, propylene glycol, PEG, paraffin alcohols

Answer 6

Emulsions (oil in water

Question 7

No preservatives or additives

ideal for topical antifungals and topical antibiotics

Answer 7

Water-soluble bases

Question 8

Organic molecules uniformly distributed in a lattice throughout the liquid

Answer 8

Gels

Question 9

Less greasy than ointments; more drying and less occlusive

Answer 9

Pastes (up to 50% powder in ointment base)

Question 10

hydroalcoholic solution with 50% alcohol

Answer 10

Tincture

Question 11

Used to dry and cool wet and weeping skin

Solutions with added powder

Answer 11

Shake lotions

Question 12

useful for scalp application

Triphasic solution with oil, organic solvents, and water, formulated with a hydrocarbon propellant

Answer 12

Foams

Question 13

ease of application to hair-bearing areas

Drug in a solution mixed with a pure propellant

Answer 13

Aerosols