Chapter 110 :: Epithelial Precancerous Lesions

Question 1

most important risk factors for the development of AKs

Answer 1

skin phenotype, cumulative UV exposure, age, and gender

Question 2

at increased risk of developing AKs

Answer 2

Immunosuppressed patients, such as organ transplant recipients

Question 3

field cancerization

Answer 3

(a) more than 2 AKs within 1 skin area with signs of solar damage, (b) at least 3 AKs within 25 cm 2 of skin, or (c) more than 5 AKs in 1 body region or field and contiguous areas of chronic actinic sun damage and hyperkeratosis

Question 4

most important contributing factors for the formation of AKs.

Answer 4

Fair skin and exposure to UV radiation

Question 5

compact packing of basal and suprabasal atypic keratinocytes with hyperchromatic and pleomorphic nuclei can be seen.

Atypic mitotic figures, apoptotic cells and dyskeratosis may be present

Answer 5

Actinic keratosis

Question 6

responsible for Bowen’s Disease lesions on hands or fingers after anodigital infection in patients that simultaneously have anal and genital lesions

Answer 6

HPV 16

Question 7

EV-plane warts share features with plane warts not associated with EV.

Dyskeratosis and pyknosis are observed more commonly in EV

Question 8

VIN differentiated type is less common than usual type and usually not associated with HPV; it affects postmenopausal females

Answer 8

VULVAR INTRAEPITHELIAL NEOPLASIA

Question 9

presents as a well-demarcated, glistening, erythematous, velvety plaque or plaques on the mucosal surfaces of the penis

Answer 9

erythroplasia of Queyrat (EQ)

Question 10

Main risk factors for the Conversion of Oral Leukoplakia into Oral Squamous Cell Carcinoma

Answer 10

Presence of epithelial dysplasia

■ Nonhomogeneous clinical subtype

■ Large size

■ Location on the tongue or the floor of the mouth