Chapter 36 :: Sweet Syndrome

Question 1

Diagnostic Criteria for Classical Sweet Syndrome

Answer 1

Abrupt onset of painful erythematous plaques or nodules
Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis Pyrexia >38o C (100.4°F) Association with an underlying hematologic (most commonly acute myelogenous leukemia) or visceral malignancy (most commonly carcinomas of the genitourinary organs, breast, and gastrointestinal tract), inflammatory disease (Crohn disease and ulcerative colitis), or pregnancy, or preceded by an upper respiratory (streptococcosis) or gastrointestinal (salmonellosis and yersiniosis) infection or vaccination
Excellent response to treatment with systemic corticosteroids or potassium iodide
Abnormal laboratory values at presentation (3 of 4): erythrocyte sedimentation rate
<20 mm/h; positive C-reactive protein; >8000/µL leukocytes; >70% neutrophils