Chapter 3: Histology Flashcards
What are the 4 major categories of tissues in the body?
Epithelial
Connective
Muscle
Nervous
What is a zygote?
a single fertilized cell that all multicellular organisms begin life as
What are the 3 primitive germ layers?
Ectoderm
Mesoderm
Endoderm
Ectoderm
primarily develops into the epidermis (top layer of skin), epidermal derivatives (glands, hair, nails), entire nervous system (brain, spinal cord, nerves) and neural components of the endocrine tissue (adrenal gland and posterior pituitary)
-Epithelial and nervous tissue
Mesoderm
primarily develops into internal epithelial structures (lining of body cavities, cardiovascular, urinary, reproductive, and lymphatic system) entire muscular system, (skeletal, smooth and cardiac muscle), endocrine structures, and connective tissue developing into the skeletal system
-Epithelial, connective, and muscle tissue
Endoderm
primarily develops into epithelial glandular derivatives of the digestive, respiratory, urinary, reproductive, and endocrine systems.
-Epithelial tissue
What are the 5 characteristics of epithelial tissue?
- Cellularity- cells tightly bound
- Polarity- one surface is attached and one is exposed
- Attachment- cells are firmly attached
- Regeneration- cells are damaged and replaced rapidly
- Avascular- does not contain blood vessels.
What are the 4 types of cellular arrangement of epithelial tissue?
Simple- single layer of cells
Stratified- multiple layers of cells
Pseudostratified- cells firmly attached to the basement membrane, but because of varied nucleus locations, it appears multi-layered.
Transitional- cells vary in shape and size depending on degree of tissue stretch, large and round cells…
What are the 3 types of cell shape for epithelial tissue?
Squamous- cells are thin, flat, and irregular in shape
Cuboidal- cube-shaped cells
Columnar- cylindrical shaped, tall cells
What are the 2 types of epithelial stratified squamous tissues?
Unkeratinized- no smooth layer at the edge (vagina)/oesophagus
Keratinized- smooth layer on the edge (skin)
what are the 5 characteristics of connective tissue?
- No cellularity- cells are not closely associated
- No polarity- all cells contained within body, no cellular surface exposed
- No attachment- cells are not attached to other tissue
- Slow regeneration- cells are not damaged easily, so division and regeneration is slow
- Vascular- they have blood vessels (except cartilage)
Proper connective tissue
wide variety of cell types and protein fibers in a thick semi-fluid ground substance
characterized into loose and dense proper CT according to concentration of protein fibers
3 types of loose CT proper
a. Areolar CT “space”, widely spaced (cushion, support, mobility)
b. Adipose CT “fat” closely associated cells (heat, energy reserve, protect, cushion)
c. Reticular CT “web” (support soft tissues) fibers coursing around organ cells
3 types of dense CT proper
a. dense regular CT (strong attachment in one direction), stabilization.
b. dense irregular CT (strong attachment in multiple directions)
c. Elastic CT (elasticity) elastic fibers allows tissue to stretch and rebound shape
What is lacunae?
spaces within the matrix housing the osteocytes.
Glandular epithelia
A type of tissue that lines certain internal organs and makes and releases substances in the body, such as mucous, digestive juices, and other fluids.
Exocrine glands
function and 3 types?
release secretions directly onto body’s external and internal body spaces
3 types:
a) Holocrine glands
b) Merocrine (eccrine) glands
c) apocrine glands
Holocrine glands
secrete their contents through process of cell lysis.
releases its secretions by disintegrating the whole cell So the entire cell breaks down to release what’s called sebum
associated with hair follicles
Merocrine (eccrine) glands
most common type of exocrine gland
secretes contents through process of exocytosis without causing any damage or loss in the secretory cel
sweat, salivary, gastric glands
Apocrine glands
secrete contents through process of exocytosis, allows large volumes of secretion without cell death.
secrete their secretions in the form of pinched-off buds or vesicles
Mammary glands and ceruminous (ear) glands
Basement membrane
glycoprotein secretion functioning to attach cells to the underlying tissue
Mesenchymal cells
embryonic connective tissue; pluripotent cells
Extracellular matrix
extra-cellular substance consisting of the ground substance and protein fibers
Ground substance
solution surrounding the cellular and fibrous components of connective tissue
Fibroblast
Connective tissue cell responsible for secreting large amounts of protein into the extracellular matrix
What are the 2 types of supportive connective tissue?
Cartilage
Bone (osseous tissue)
What are the 3 types of cartilage?
Hyaline
fibrocartilage
Elastic
What are the 2 types of bone (osseous tissue)?
Compact bone (dense)
Spongy bone
Hyaline cartilage
Characteristics and function
most abundant and weakest cartilage
tough but somewhat flexible
thin groups of collagen fibers
Fx: reduces friction, provides stiff but somewhat flexible support and protection
Elastic cartilage
Characteristics and function
Most flexible, large amount of elastic fibers
support and flexibility
Fx: support and maintain shape
Fibrocartilage
Characteristics and function
strongest cartilage
interwoven, thick collagen fibers
Fx: resist compression, prevent bone to bone contact, limit joint motion
Compact bone (dense bone)
-contains few spaces between bony matrix
-forms outer wall of bones
-arrangement of matrix and osseous cells
-have lamella, lacuna, central canal, canaliculi, osteoctyes, and a calcified matrix
Central canal
forms center of osteon or haversion system.
open space in bony matrix allowing passage of blood vessels & nerves,
supply blood to active osteocytes
Lamellae
rings of bony matrix around central canal and resident blood vessels
Canaliculi
small canals connecting osteocytes within lacunae to central blood vessels
allows for better diffusion and access to nutrients
Perforating (Volkmann’s) canal
communicating canals connecting adjacent central canals, allowing blood flow between adjacent osteons
What are the 4 types of bone cells?
- Osteoprogenitor cells “bone”
-unspecialized bone cell that can become active - Osteoblasts “bud or germ”
-active bone matrix forming cells
-produces osteoid which calcifies to hard bone - Osteoctye “cell”
-mature bone cells derived from osteoblast
-maintenance of surrounding osseous tissue - Osteoclast “break”
-breakdown of matrix, re absorption of osseous tissue
spongy bone
Characteristics & function (Fx)
-forms core of most bones and ends of long bones
-composed of lattice of interlocking beams/struts of bony matrix
-retrieve nutrients directly from surrounding blood
Bony beams are called Trabecula (spongy appearance)
Spaces between trabecula filled with blood forming cells comprise the red bone marrow