Chapter 18 Flashcards
Whole Blood
Plasma and formed elements; separated into parts by a centrifuge
Erythrocytes
Red Blood Cells; 44% of whole blood; transport respiratory gasses in the blood; anucleated; short lifespan; packed with hemoglobin
Buffy Coat
Composed of leukocytes and platelets
Plasma
55% of whole blood; fluid portion of blood; contains plasma proteins and dissolved solutes; extracellular fluid; higher protein concentration to interstitial fluid
Leukocytes
White blood cells; defend against pathogens; immune system cells
Platelets
Thrombocytes; help form clots to prevent blood loss; anucleated; circulate for 8-10 days then broken down and recycled; membrane-enclosed cell fragments
Functions of blood
Transportation; protection; Regulation of body conditions; body temperature; body ph; fluid balance
Albumins
Smallest and most abundant plasma proteins; exert the greatest osmotic pressure; act as transport proteins for some lipids, hormones, and ions;
Gobulins
alpha-gobulins are smaller; beta-gobulins are smaller; transport some water-insoluble molecules, hormones, metals, ions
Fibrinogen
makes up 4% of plasma proteins; contributes to blood clot formation
Regulatory Proteins
includes enzymes and hormones
Hematocrit
Volume of all formed elements; percentage of erythrocytes; Males have a slightly higher percentage than females due to testosterone
Hemopoiesis
production of formed elements; occurs in red bone marrow
Hemocytoblasts
Blood stem cells
Pluripotent
can differentiate into many types of cells; Myeloid line and lymphoid line
Myeloid Line
forms erythrocytes, and all leukocytes except lymphocytes
Lymphoid Line
forms only lymphocytes
Colony-Stimulating Factors
stimulate hemopoiesis
Erythropoiesis
red blood cell production
Leukopoiesis
production of leukocytes
Thrombopoiesis
platelet production
Hemoglobin
red-pigmented protein; transports oxygen and carbon dioxide; Composed of four globins; oxygen bonds to iron weakly; carbon dioxide binds to globin protein weakly
Agglutination
Caused by incompatible blood transfusions; recipient antibodies bind to erythrocytes and clump them together;
Granulocyte
has granules with enzymes that are released (Neutrophil, eosinophil, basophil)
Agranulocyte
No granules; lymphocyte and monocyte
Neutrophils
50-70% of total leukocytes; phagocytize pathogens; granulocyte
Basophils
Release granules containing chemicals that attract immune cells; granulocyte
Eosinophils
Phagocytize antigen-antibody complexes and parasites; granulocyte
Monocytes
2-8% of total leukocytes; exit blood vessels and become macrophages; phagocytize pathogens and cellular fragments; agranulocyte
Lymphocytes
20-40% of total leukocytes; coordinate immune cell activity; attack pathogens and abnormal and infected cells; produce antibodies; adaptive immunity; agranulocyte
T-lymphocytes
effective against antigen within cells; requires antigen-presenting cell
B-lymphocytes
effective against antigen outside cells; does not require antigen-presenting cell
Natural Killer Cells
Destroy unhealthy and unwanted cells by releasing cytotoxic chemicals
Hemostasis
stoppage of bleeding; vascular spasm, platelet plug formation, coagulation phase
Vascular Spasm
blood vessel constricts to limit blood escape
Platelet Plug Formation
Platelets arrive at site of injury and stick to exposed collagen fibers
Coagulation Phase
Coagulation converts inactive proteins to active forms which ultimately forms fibrin strands of a blood clot
Hemophilia
Bleeding disorder caused by genetic mutations; X-linked recessive inheritance; more likely seen in males
Surface Antigens
Project from erythrocyte membrane (A antigens on type A blood)
Rh Factor
determines if blood type is positive or negative; only appear after negative person is exposed to positive blood
Innate Immunity
Provided by multiple components that protect against a wide array of substances (skin and mucosal membrane and non specific internal defenses (immune cells, chemicals, physiologic responses of inflammation and fever)
Adaptive Immunity
provided by lymphocytes that are activated to replicate and respond when stimulated by a specific antigen
Leukemia
malignancy in leukocyte-forming cells; abnormal development and proliferation of leukocytes; results in anemia and bleeding
Plasma and formed elements; separated into parts by a centrifuge
Whole Blood
Red Blood Cells; 44% of whole blood; transport respiratory gasses in the blood; anucleated; short lifespan; packed with hemoglobin
Erythrocytes
Composed of leukocytes and platelets
Buffy Coat
55% of whole blood; fluid portion of blood; contains plasma proteins and dissolved solutes; extracellular fluid; higher protein concentration to interstitial fluid
Plasma
White blood cells; defend against pathogens; immune system cells
Leukocytes
Thrombocytes; help form clots to prevent blood loss; anucleated; circulate for 8-10 days then broken down and recycled; membrane-enclosed cell fragments
Platelets
Transportation; protection; Regulation of body conditions; body temperature; body ph; fluid balance
Functions of blood
Smallest and most abundant plasma proteins; exert the greatest osmotic pressure; act as transport proteins for some lipids, hormones, and ions;
Albumins
alpha-gobulins are smaller; beta-gobulins are smaller; transport some water-insoluble molecules, hormones, metals, ions
Gobulins
makes up 4% of plasma proteins; contributes to blood clot formation
Fibrinogen
includes enzymes and hormones
Regulatory Proteins
Volume of all formed elements; percentage of erythrocytes; Males have a slightly higher percentage than females due to testosterone
Hematocrit
production of formed elements; occurs in red bone marrow
Hemopoiesis
Blood stem cells
Hemocytoblasts
can differentiate into many types of cells; Myeloid line and lymphoid line
Pluripotent
forms erythrocytes, and all leukocytes except lymphocytes
Myeloid Line
forms only lymphocytes
Lymphoid Line
stimulate hemopoiesis
Colony-Stimulating Factors
red blood cell production
Erythropoiesis
production of leukocytes
Leukopoiesis
platelet production
Thrombopoiesis
red-pigmented protein; transports oxygen and carbon dioxide; Composed of four globins; oxygen bonds to iron weakly; carbon dioxide binds to globin protein weakly
Hemoglobin
Caused by incompatible blood transfusions; recipient antibodies bind to erythrocytes and clump them together;
Agglutination
has granules with enzymes that are released (Neutrophil, eosinophil, basophil)
Granulocyte
No granules; lymphocyte and monocyte
Agranulocyte
50-70% of total leukocytes; phagocytize pathogens; granulocyte
Neutrophils
Release granules containing chemicals that attract immune cells; granulocyte
Basophils
Phagocytize antigen-antibody complexes and parasites; granulocyte
Eosinophils
2-8% of total leukocytes; exit blood vessels and become macrophages; phagocytize pathogens and cellular fragments; agranulocyte
Monocytes
20-40% of total leukocytes; coordinate immune cell activity; attack pathogens and abnormal and infected cells; produce antibodies; adaptive immunity; agranulocyte
Lymphocytes
effective against antigen within cells; requires antigen-presenting cell
T-lymphocytes
effective against antigen outside cells; does not require antigen-presenting cell
B-lymphocytes
Destroy unhealthy and unwanted cells by releasing cytotoxic chemicals
Natural Killer Cells
stoppage of bleeding; vascular spasm, platelet plug formation, coagulation phase
Hemostasis
blood vessel constricts to limit blood escape
Vascular Spasm
Platelets arrive at site of injury and stick to exposed collagen fibers
Platelet Plug Formation
Coagulation converts inactive proteins to active forms which ultimately forms fibrin strands of a blood clot
Coagulation Phase
Bleeding disorder caused by genetic mutations; X-linked recessive inheritance; more likely seen in males
Hemophilia
Project from erythrocyte membrane (A antigens on type A blood)
Surface Antigens
determines if blood type is positive or negative; only appear after negative person is exposed to positive blood
Rh Factor
Provided by multiple components that protect against a wide array of substances (skin and mucosal membrane and non specific internal defenses (immune cells, chemicals, physiologic responses of inflammation and fever)
Innate Immunity
provided by lymphocytes that are activated to replicate and respond when stimulated by a specific antigen
Adaptive Immunity
malignancy in leukocyte-forming cells; abnormal development and proliferation of leukocytes; results in anemia and bleeding
Leukemia