Chapter 13: The Endocrine System Flashcards
parathyroid glands
- located on posterior surface of the thyroid
- usually 4 parathyroid glands
- secrete 1 hormone, PTH
PTH
regulates calcium and phosphate concentration in blood; antagonistic of calcitonin
actions of PTH
- increase blood calcium levels
- decrease blood phosphate levels
- exerts effects by acting on bones, kidneys, intestines
- indirectly stimulates absorption of calcium by stimulating a step in vitamin D metabolism
- acts on kidneys to cause final step in production of vitamin D
hyperparathyroidism
increase PTH secretion overstimulates osteoclasts; caused by tumors
hypoparathyroidism
decrease PTH secretion reduces osteoclasts; caused by injuries
adrenal glands
- aka superenal
- hormones are secreted from two different areas of gland
- numerous hormones are secreted by the adrenal glands
- adrenal hormones play roles in maintaining blood sodium levels and stress response; include some sex hormones
where are hormones secreted from in the adrenal glands?
adrenal cortex & adrenal medulla
adrenal cortex
outer portion, secretes steroid hormones
adrenal medulla
central portion, secretes amine hormones
what hormones does the adrenal cortex secrete?
cortisol, aldosterone, & adrenal androgens
what hormones does the adrenal medulla secrete?
epinephrine & norepinephrine
aldosterone
concentration of electrolytes by preserving sodium & excreting potassium
cortisol
decrease protein synthesis, increases fatty acid release, glucose synthesis from non carbs
adrenal androgens
supplement sex hormones from gonads
how many zones does the adrenal cortex have?
3; each producing different types of hormones
3 zones of adrenal cortex
- zona glomerulosa
- zona fasciculata
- zona reticularis
zona glomerulosa
- outer
- produces aldosterone & other mineralocorticoids
zona fasciculata
- middle
- produces cortisol & other glucocorticoids
zona reticularis
- inner
- produces male sex hormones
renin-angiotensin system
- helps maintain normal blood pressure
- product of system, angiotensin II, increases blood pressure & promote secretion of aldosterone
what does aldosterone do?
conserves sodium & water is retained by osmosis
increased blood volume =
increased blood pressure
how is cortisol secretion regulated?
by a 3 step hormone pathway; exerts negative feedback on its own production pathway
pancreas
- elongated, flat
- posterior to stomach
- pancreatic duct transports digestive juice to duodenum
- endocrine portion consists of groups of cells call pancreatic islets
how many types of secretory tissue does the pancreas include?
2; endocrine & exocrine
endocrine function in pancreas
secretes hormones into body fluids
exocrine function in pancreas
secretes digestive juices through a duct
3 hormones secreted from endocrine (islet) cells
- alpha
- beta
- delta
alpha
insulin
beta
glucagon
delta
somatostatin
addison’s disease
insufficient hormone secretion from adrenal cortex
cushings disease
hypersecretion of cortisol, usually due to tumor; causes swelling of face
insulin
decreases blood glucose when too high
glucagon
increases blood glucose when too low
somatostatin
helps regulate glucose metabolism by inhibiting secretion of insulin & glucagon
type 1 diabetes
insulin dependent, autoimmune, no blood glucose regulation
type 2 diabetes
insulin independent; body cells do not recognize insulin
pineal gland
- secretes melatonin
- regulates circadian rhythms
thymus gland
- secretes thymosins
- promotes development of T-lymphocytes
- important in role of immunity
reproductive organs
- ovaries produce estrogen & progesterone
- testes produce testosterone
- placenta produce estrogen, progesterone, and gonadotropin
responses to stress
- hypothalamus controls stress response
- response call general adaptation or general stress syndrome
2 stages of general stress syndrome
- alarm
- resistance
alarm response
- immediate
- fight or flight
- sympathetic impulses increase blood glucose, heart & respiratory rate, blood pressure, shunt blood to skeletal muscles
- epinephrine intensifies and prolongs response
resistance response
- long term
- increased cortisol spares glucose for brain
- glucagon & GH mobilize energy sources for other tissues & organs
- ADH & renin cause water retention