Cardiología: Antiagregantes Flashcards

1
Q

¿Cuales son los farmacos antiagregantes?

A

aspirina, clopidrogel, abciximab, tirofiban

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2
Q

Inhiben hemostasia primaria

A

antiagregantes

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3
Q

Formacion de un tapon, consta de 3 pasos: adhesion, activacion, agregacion

A

hemostasia primaria

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4
Q

formacion de un coagulo, consta de 3 vias: extrinseca, intrinseca, comun

A

hemostasia secundaria

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5
Q

mecanismo de acción de la aspirina

A

inhibidor reversible de COX, en dosis bajas inhibe sintesis de TXA2

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6
Q

se usa para prevencion de trombosis arterial (secundaria), tx coadyuvante de IAM, accidente isquemico transitorio y protesis valvulares

A

aspirina

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7
Q

EA de la aspirina

A

hemorragia de tracto gastrointestinal

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8
Q

disminuye trombosis arterial en px con SCA (angina inestable, nSTEMI y STEMI)
Prevencion secundaria despues de MI y EVC

A

clopidogrel, prasugrel, ticagrelor

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9
Q

mecanismo de accion de clopidogrel, prasugrel y ticagrelor

A

bloquean los receptores de difosfato P2Y12 plaquetarios

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10
Q

EA del clopidogrel, prasugrel y ticagrelor

A

aumenta riesgo de hemorragia, IBPs disminuye ativacion (CYP2C19) de estos antiagregantes

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11
Q

Son antagonistas de la glucoproteina IIb/IIIa

A

abciximab y tiofiban

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12
Q

previene trombosis coronaria en angina inestable

A

tirofiban

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13
Q

disminuye la agregacion plaquetaria y trombosis en px intervenidos de angioplastia coronaria y con uso de endoprotesis vasculares. Previene significativamente la reestenosis vascular, reinfarto y el fallecimiento

A

abciximab

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14
Q

mecanismo de accion del abciximab

A

anticuerpo monoclonal anti GP 2b/3a

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15
Q

mecanismo de accion del tirofiban

A

antagonista reversible de GP 2b/3a

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16
Q

EA del abciximab y tirofiban

A

aumenta riesgo de hemorragia (gastrointestinal, urinaria, intracraneal)

17
Q

Vasodilatan e inhiben la agregacion plaquetaria, son inhibidores de la fosfodiesterasa. Aumentan cAMP

A

dipiridamol y cilostazol

18
Q

compite por la union del fibrinogeno al GP2b/3a

A

eptifibatida

19
Q

bloquea receptor activado por proteasa 1 (PAR-1), coadyuvante de otros farmacos

A

vorapaxar