C/9 Cephalosporins

Question 1

Cephalexin

Answer 1

1st gen. Oral

Question 2

Cephazolin

Answer 2

1st gen. Parenterally.

Surgical prophylaxis

Question 3

Cefuroxime axetil

Answer 3

2nd gen. Oral

Question 4

Cefuroxime

Answer 4

2nd gen. Parenterally

Question 5

Cefoxitine

Answer 5

2nd gen. Parenterally. Cephamycin

High activity against anaerobic bacteria
Good for mixed aerobic-anaerobic infections (peritonitis, diverticulitis)

Question 6

Cefixime

Answer 6

3rd gen. Orally

1st line treatment of gonorrhea

Question 7

Ceftriaxone

Answer 7

3rd gen. Parenterally. Long half life. Liver excretion

Contraindicated in premature newborns (jaundice)

Question 8

Cefotaxime

Answer 8

3rd gen. Parenterally. Short half life.

Used in premature newborns

Question 9

Ceftazidime

Answer 9

3rd gen. Parenterally.

Pseudomonas

+avibactam for complicated UTI or IAI, ESBL, carbapenamase producing strains, nosocomial pneumonia

Question 10

Cefepime

Answer 10

4th gen. Parenteral. Kidneys

For life threatening and severe infections

Question 11

Ceftolozane + tazobactam

Answer 11

4th gen.

For complicated UTI or IAI, ESBL, carbapenemase producing strains, Pseudomonas

Question 12

Ceftaroline fosamil

Answer 12

5th gen. Parenteral

Prodrug: ceftaroline is the active metabolite

MRSA