C/12 Tetracyclines, Glycyclines

Question 1

Doxycycline

Answer 1

Tetracycline
30S. Bacteriostatic.
Resistance due to efflux pump or ribosomal protection

Divalent cations influence absorption

Disturbs bone and teeth formation in children, dysbacteriosis, candidiasis, photosensitivity

Question 2

Tigecycline

Answer 2

Glycylcycline
Tetracycline-like drug, but not the substrate of the efflux pump.

Broad spectrum

Gram pos cocci (inkl MRSA, VRSA), gram pos rods, IC, gram neg (not Pseu, prote), anaerobic inf