C/17 Glycopeptides, Fusidans, Lipopeptides, Bacitracin, Mupirocin

Question 1

Vancomycin

Answer 1

Glycopeptide AB

MRSA, Enterococcus

Question 2

Teicoplanin

Answer 2

Glycopeptide AB

Same indications as vancomycin

Ototoxicity

Question 3

Oritavancin

Answer 3

Glycopeptide AB

Question 4

Bacitracin

Answer 4

Inhibits cell wall biosynthesus (peptidoglycan subunit transfer),

Gram pos

Nephrotoxic

Only topical application

Question 5

Daptomycin

Answer 5

Lipopeptide

Incorporated into cell membrane —> depol —> cell death

Polyresistant gram pos cocci

Myopathy, CK elevation

Inactivated by surfactant, so don’t use in pneumonia

Question 6

Fusidic acid

Answer 6

Fusidan. Inhibits protein synthesis

Gram pos bacteria. Severe staph infections, inkl. MRSA, corynebacterium endocarditis, combo with other ABs to prevent resistance

Nausea, vomiting, liver, icterus

Question 7

Mupirocin

Answer 7

Binds to isoleucyl tRNA synthetase, resulting in inhibition of protein synthesis

Gram pos cocci

Topical treatment of bacterial skin infections, including MRSA