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Pharmacology > B/29 Immunopharmacology: Cytotoxic agents, retinoids, Autoimmune diseases > Flashcards

B/29 Immunopharmacology: Cytotoxic agents, retinoids, Autoimmune diseases Flashcards

1
Q

Cyclophosphamide

A

Alkylating agent

Activated in the liver

Used in cancer treatment and immunosuppression

Adverse effects: BM suppression, teratogenic, GI, lung fibrosis, hemorrhagic cystitis, reproductive organ dysfunction, oligospermia

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2
Q

Methotrexate

A

Antimetabolite: folic acid antagonist

Inhibits DHF reductase
Used in anti cancer treatment and immunosuppression

Eliminated by the kidney

Adverse effects: mucositis, GI, liver and kidney toxicitym alopecia, BM toxicity, lung fibrosis

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3
Q

Leflunomide

A

?

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4
Q

Azathioprine

A

Antimetabolite: purine antagonist

Metabolized by HGPRT and inhibits de novo purine synthesis. Incorporates into RNA and DNA

ALL

Adverse effects: myelotoxicity, GI, anorexia, hyperuricemia

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5
Q

Mycophenolate-mofetil

A

?

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Pharmacology (26 decks)

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