Blood Disorders pt 1 Flashcards
hemoglobinopathies
a group of disorders in which there is abnormal production or structure of the hemoglobin molecule.
how does sickle cell disease occur
a Glu is replaced with Val in the beta chain of hemoglobin
what is a megaloblast
abnormally large erythroid precursors
what is hemolytic anemia
RBCs destroyed faster than they can be made
what is aplastic anemia characterized by (3 things)
reduction of hematopoietic tissue
fatty marrow replacement
pancytopenia
what are some clinical manifestations of pernicious anemia
megaloblastic madness
paresthesia of the feet and hands - proprioception disturbances
what are the symptoms for moderate to severe anemia
hypotension
tachynea/dyspnea
tachycardia, transient murmurs, angina, HF
claudication, night cramps
headaches/lightheaded
tinnitus
what are some common causes of anemia
blood loss
impaired RBC production
increased RBC destruction
Describe the RBC indices for thalassemia
MCV: low
MCH: low
MCHC: norm/dec
Platelets: norm
RBC: inc
WBC: inc
Hb: low
Hct: low
Standard lab values for RBC count
M: 4.2-5.4x10^6/mL
F: 3.6-5.0x10^6/mL
Standard lab values for hemoglobin test
M: 14-16.5g/dL
F:12-15g/dL
what are some causes of b12 deficiency (3)
damage/atrophy of parietal cells in stomach
resectioning of stomach or SI
chronic malabsorption (chrons, aids)
Standard lab values for MCH
27-34 pg/cell
what are globin chains
the alpha and beta chain aspect of hemoglobin
Petechia
small blood vessels leak under skin (under 4mm)
how can we treat aplastic anemia
manage symptoms via transfusion
bone marrow transplant
immunosuppression therapy
what is hereditary spherocytosis
a disorder of the RBC membrane
Describe the RBC indices for chronic kidney failure
MCV: normal/slight dec
MCH: norm/slight dec
MCHC: normal/slight dec
Platelets: decreases as the kidney failure gets worse
RBC: low
WBC: normal/slight inc
Hb: low
Hct: low
genetic aplastic anemia - causes pancytopenia due to defects in DNA repair
Fanconi anemia
what are the symptoms for mild to moderate anemia
fatigue
weakness
loss of stamina
tachycardia
exertional dyspnea
what causes occlusions with SCD
sickled RBCs are not able to pass through membranes and get blocked up
What are some causes of folate deficiency
dietary
alcoholism
cirrhosis
pregnancy
malabsorption
what is the treatment for anemia of chronic kidney failure
epo therapy
What does the reticulocyte test tell us
Percent of immature RBCs
Describe the RBC indices for Sickle Cell
lots of different shapes and sizes
Platelets: norm
WBC: norm
what genes is thalassemia associated with
mutant genes that suppress the rate of globin chain synthesis
What does the RBC count tell us
number of RBCs per mL of blood
B12 and folate are required for what
nuclear maturation and DNA synthesis
how do you diagnose aplastic anemia
bone marrow biopsy
what are the 2 compensatory mechanisms for hypoxia from anemia
increase BF (HR, CO)
restore tissue oxygenation
what hormone stimulates RBC production in response to low pO2
erythropoietin
Describe the RBC indices for aplastic anemia
MCV: normal
MCH: norm/slight dec
MCHC: normal
Platelets: low
RBC: low
WBC: low
Hb: low
what are two common cardiovascular complications due ot sickle cell disease
chamber enlargement
myocardial infarction
What are the terms for a normal and low MCHC
normochromic
hypochromic
Purpura
small blood vessels leak under skin (4-10mm)
what are 3 clinical manifestations of folate deficiency
demeanor change - depression, irritability, sleep deprivation
memory impairment
perversions of smell and taste
Standard lab values for Reticulocyte test
1-1.5% of total RBC
what is aplastic anemia caused by
toxic, radiant or immunological injury to bone marrow stem cells
Anemia
reduction in the total number of erythrocytes/decrease in quality/quantity of hemoglobin
Relative anemia
normal total red cell mass with disturbances in regulation of plasma volume
Absolute anemia
actual decrease in numbers of RBCs