Blood and Lymph Flashcards
What is a liquid connective tissue that consists of cells surrounded by extracellular matrix?
Blood
What are the three general functions of blood?
Transportation
Regulation
Protection
What does blood transport?
Oxygen Carbon dioxide nutrients heat waste hormones
What does blood regulate in the body?
pH
Heat
Blood osmotic pressure
How does the blood protect the body?
Blood Clots Disease (WBC) -phagocytosis -antibodies -interferons -complement
What is the temperature of blood?
100.4F or 38C
What is the pH of blood?
7.35 to 7.45
How much of the total body weight does blood constitute for?
8%
What is the average blood volume for males and females?
M- 5-6L
F- 4-5L
Whole blood is composed of what two parts?
Blood plasma
Formed Elements
What percentage of blood is formed elements?
45%
What is a liquid extracellular matrix that contains dissolved substances?
Blood plasma
Formed elements of the blood are what?
Cells and cell fragments
What percentage of formed elements is made up of red blood cells?
99%
What constitutes 1% of formed elements?
White blood cells and platelets
Plasma is what percentage of the blood volume?
55%
What is the percentage of total blood volume occupied by red blood cells?
Hematocrit
What is the normal range of HCT for males and females?
M- 42-52%
F- 37-47%
What is the buffy coat made up of?
WBC and platelets
What does blood plasma consist of and what are the percentages?
91.5% water
7% protein
1.5% solutes
Where are proteins in the blood synthesized?
mainly in the liver
What is the most plentiful plasma proteins?
Albumins-54%
Fibrinogen-7%
What oxygen-carrying protein is contained by RBCs and gives red pigmentation of the cell?
Hemoglobin
Hemoglobin carries about what percentage of carbon dioxide in the blood?
23%
What is the RBC count for males and females?
M- 5.4m
F- 4.8m
RBCs live for how long?
120 days
What is the normal level of WBCs in the body?
5-10k/uL
What is the life span of a WBC?
few hours to days
What is the main differences of WBCs and RBCs?
WBCs-have nuclei and organelles do not contain hemoglobin
What are the two classifications of WBCs?
Granular and agranular
What are the granular leukocytes?
Neutrophils
Eosinophils
Basophils
Neutrophils account for what percentage of WBCs and carry out what action?
50-70%
Phagocytosis
-destroy bacteria with lysozymes, defensins and strong oxidants
What percent of WBCs is Eosinophils and what is their function?
1-5%
Suppress effects of histamine
Phagocytizes antigen-antibody complexes
Destroys certain parasitic worms
What percentage of WBCs are Basophils and what is their function?
0-1%
Releases heparin, histamine and serotonin to intensify inflammatory response in allergic reactions
What are the agranular leukocytes?
Lymphocytes
Monocytes
Lymphocytes include what cells?
T
B
Natural Killer
What percentage of all WBCs are leukocytes and what is their function?
20-40% Mediates immune responses B cells transform to plasma T cells attack viruses, cancer and transplanted cells NK cells attack microbes and tumor cells
Monocytes are what percentage of WBCs and what is their function?
1-6%
Phagocytic
-transform to a fixed histiocyte or wondering macrophage
What is the normal platelet count in an adult?
150k to 400k/uL
Platelets live for how long?
5-9 days
Platelets form platelet plugs during hemostasis that do what?
Release chemicals to promote vascular spasm and blood clotting
What is the process by which the formed elements of blood develop?
Hemopoiesis
What is the primary site of hemopoiesis?
Red bone marrow
What type of cells have the capacity to develop into different cell types?
pluripotent stem cells
Stem cells can further differentate into what cell lines?
myeloid and lymphoid
What cells can myeloid stem cells differentiate into?
Red cells Platelets Mast Cells Eosinophils Basophils Neutrophils Monocytes
Lymphoid stem cells develop in the marrow but mature in lymphatic tissue are what?
T cells
B Cells
Natural Killer Cells
Immature cells in peripheral blood are known as what?
Bands and Blasts
What is a left shift? And what does it indicate?
> 10% bands
body is fighting infection over long period of time that doesn’t allow bone marrow to keep up
Blast, the most immature cells, are associated with what?
myelodysplastic disorders
What in the blood loss mechanism must be quick, localized to the region of damage and carefully controlled?
Hemostatic response
What is defined as a sequence of responses that stops bleeding when vessels are injured?
Hemostasis (stasis-standing still)
What are the three mechanisms that can reduce loss of blood?
Vascular spasm
Platelet plug
Blood clotting
What response occurs when the smooth muscles of the vessel wall contract?
vascular spasm
What are the steps of a platelet plug formation?
Platelets contact and stick to damage vessel via collagen fibers
Platelets interact with each other and liberate chemicals
Chemicals activate nearby platelets and sustain vascular spasm
Eventually enough platelets form a mass called platelet plug
What is the straw-colored liquid called that is plasma without the clotting proteins?
Serum
What is the insoluble protein fibers that make up a clot called?
Fibrin
What is the process of clot formation called?
Clotting or coagulation
What elements do clotting factors include?
Calcium ions (Ca2+) Potassium (K)
Clotting factors are identified by what?
Roman numerals
What are the steps of the common pathway?
1-Prothombinase is formed
2-Prothombinase converts prothrombin into enzyme thrombin
3-Thrombin converts fibrinogen into insoluble fibrin
What forms the threads of a clot?
Fibrin
What habit can interfere with the production of fibrin?
Smoking
What is the consolidation or tightening of a fibrin clot that pulls the edge of damaged vessels closer called?
Clot retraction
Fibroblasts form what in the rupture area?
Connective tissue
What is the enzymatic breakdown of fibrin in a clot called?
Fibrinolysis
What is the inactive plasma enzyme created when a blood clot is formed called?
plasminogen
Plasminogen is activated to form plasmin that does what?
Digest and dissolves fibrin threads, removing the clot.
What can roughen endothelial surfaces of a blood vessel?
Atherosclerosis
Trauma
infection
What is clotting in an unbroken vessel called?
Thrombosis
What is the term for a thrombus that has dislodged and swept away in blood?
Embolus
What is the most common site for a embolus to be lodged?
Lungs
Antigens on a RBC are composed of what?
Glycolipids and glycoproteins
Antigens that occur in characteristic combinations are called?
Agglutinogens
There are at least how many blood groups?
24
What are the two major blood groups?
ABO and RH