Biochem: Pathways Flashcards
RLS of UREA cycle?
Co2 and NH3 with 2 ATP for form carbamoyl phosphate by carbamoyl phosphate synthetase 1.
INSIDE mitochondria!
Where are the 2 nitrogens of urea DIRECTLY from?
NH3 and aspartate. But both are essentially from glutamate that harvests from other amino acids.
2 transport forms of ammonia?
Which one used by brain?
Urea and glutamine.
Glutamine.
Inhibitors of ala synthase
Against heme synthesis
Phenobarbital
Griseofulvin
Hydantoin
Which step in heme synthesis is a ring first formed?
Uroporphyrinogen synthase 3
Synthesis or uroporphyrinogen 3
What is the committed step in the formation of purines?
The synthesis of 5-phosphoribosylamine.
INHIBITED by amp gmp imp (parent purine) the end products
What drug inhibits the formation of GMP from IMP thereby inhibiting rapidly proliferating b and T cells. Useful for transplants.
Mycophenolic acid
What is the regulated step in pyramidine synthesis?
Synthesis of carbamoyl phosphate from glutamine and co2 by CPS2
What drug inhibits the formation of dUMP to dTMP?
How about DHF to THF?
5FU by masquerading as fDUMP and fooling thymidylate synthase
Methotrexate
What blocks the conversion of cholesterol to pregnenolone in the steroid hormone synthesis?
Aminogluthetimide
What is the most common enzyme defect in glycolysis?
Pyruvate kinase deficiency
Presents as chronic hemolytic anemia
