Antibiotics Flashcards
What is bacteriostatic antibiotic
Inhibits growth of bacteria
What is bactericidal antibiotic
Kills bacteria
What are 2 spectrums of antibiotics
Narrow (either gram pos or neg)
Broad (Active against all groups)
What is selective toxicity
Minimal damage to host as inhibits bacteria feature not present in human cells
Ideal antibiotic characteristics
Selective toxicity
Cidal
Long half life
Appropriate distribution
No adverse drug interactions
Oral preparations
Where do antibiotics target
Cell walls
Ribosomes
Nucleic acids
Folic acid synthesise
What is antibiotic pharmodynamics
How much you have,
How long its present in the blood
-Concentration it maintains
What is antibiotic Pharmokinetics
Delivery of antibiotic & how body deals with it
Absorption and elimination
What inhbit cell wall synthesis
Penicillin’s
Cephalosporins
Glycopeptides
Beta lactam cell wall targeting antimicrobials
Penicillin’s
Cephalosporins
Carbapenems
Mechanism of B lactam antibiotics
Inhibits transpeptidase by binding to PBP
stopping cross linking of D-alanine and D-lysine amino acids
peptidoglycan layers peel away
Gram positive penicillin
Flucloxacillin
Gram pos + neg penicillin
Amoxicillin,
Co-amoxiclav
Tazocin (Piperacillin + Tazobactam)
Gram neg penicillin
Temocillin
Cell wall targeting antibiotic NOT B lactam
Glycopeptides
