Anectine (succinocholine)

Question 1

Anectine (class)

Answer 1

depolarizing neuromuscular blocking agent

Question 2

Anectine (MOA)

Answer 2

skeletal and respiratory muscle paralysis

prevents neuromuscular transmission by blocking ACH at NM junction

has no analgesic or anxiolytic effects

Question 3

Anectine (indications)

Answer 3

RSI

skeletal muscle paralysis to facilitate ET

Question 4

Anectine (dosage/route)

Answer 4

1-2mg/kg rapid IV/IO push (10-30secs)

Question 5

Anectine (side effects)

Answer 5

prolonged paralysis

hypotension

bradycardia (esp in children)

malignant hyperthermia

Question 6

Anectine (contraindications)

Answer 6

known hypersensitivity

known or suspected hyperkalemia

history of malignant hyperthermia or rhabdomyolysis

penetrating eye injuries

Question 7

Anectine (special information)

Answer 7

should not be administered unless alternate advanced airway techniques are available

all ET equipment, medications, personnel, & safeguards must be immediately available and working prior to administration

causes muscle fasciculations and progresses to paralysis

paralysis onset 30-60 seconds and lasts for 5 minutes

has no effect on conscious pain. pt should always be sedated first

more common as 2nd line induction if etomidate does not work or is contraindicated

children are not as sensitive and may require higher dose

Question 8

Anectine (pediatric note)

Answer 8

not recommended unless no other option to secure immediate airway

children <6yo: 2mg/kg IV/IO