Addison's and Cushing's and Pheochromocytoma Flashcards

1
Q

What is the inner layer of the adrenal gland?

A

Medulla

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2
Q

What is the outer layer of the adrenal gland?

A

Cortex

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3
Q

What does the adrenal cortex release?

A

Glucocorticoids, Mineralocorticoids, Androgenic hormones

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4
Q

What does the adrenal medulla release?

A

Catecholamines
-Epinephrine (heart rate and respiratory rate)
-Norepinehrine (blood pressure)

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5
Q

What are examples of the different steroids in the adrenal cortex?

A
  1. Cortisol (stress hormone) and glucose
  2. Aldosterone
  3. Estrogen and testosterone
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6
Q

What is the cause of Addison’s disease?

A
  1. Hypofunctional adrenal gland
  2. Autoimmune condition
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7
Q

What are the manifestations of Addison’s in terms of hormones?

A

Low sugar, salt, androgen, and norepi but high epi

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8
Q

What are the manifestations of low sugar?

A
  1. Inability to tolerate stress (cortisol)
  2. hypoglycemia
  3. Inability to produce melanin stimulating hormone
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9
Q

What is a common symptoms of Addison’s patients in terms of skin?

A

Bronze skin

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10
Q

What are the manifestations of low salt?

A
  1. Fluid Volume Deficit
  2. Hyonatremia and Hyerkalemia
    - Altered LOC
    - Seizure
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11
Q

What are the manifestations of low androgens?

A

Poor amount of axillary/pubic hair

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12
Q

What is the manifestation of low norepinephrine?

A

Hypotension

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13
Q

Why does the epinephrine increase instead of decrease?

A

Acts as a compensatory mechanism

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14
Q

What are the manifestations of Addisonian Crisis?

A

Tachycardia, tachypnea, hypotension

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15
Q

What is the management of Addisons?

A
  1. Reduce stress
  2. High sodium low potassium diet
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16
Q

What drugs are given to patients with Addisons?

A
  1. Prednisone (gluco)
  2. Fludrocortisone (mineral)
    - WOF infection
    - take with food
17
Q

What causes Cushing’s?

A

High ACTH
1. Tumor
2. Autoimmune condition

18
Q

What occurs in Cushing’s?

A

Opposite of Addison’s, everything goes up

19
Q

What is the manifestation of high sugar?

A
  1. Irritability (high cortisol)
  2. Hyperglycemia
    - sluggish blood flow
    - risk for infection and fracture
20
Q

What is manifestation of high salt?

A
  1. hypernatremia
    - altered LOC
    - seizure
  2. Fluid Volume Excess
21
Q

What are the manifestations of fluid volume excess in cushing’s

A
  1. Moon face
  2. Buffalo hump
  3. Truncal obesity
  4. Weight gain
22
Q

What is the manifestation of high androgen?

A
  1. Hirsutism (hair growth in female)
  2. Gynecomastia
23
Q

What is the manifestation of high epi and norepi?

A

Hyertensive crisis (tachycardia, tachypnea, hypertension)
- risk for MI

24
Q

What is the management of Cushing’s?

A
  1. Monitor intake and output
  2. Weight monitoring
  3. Monitor for infection (hyperglycemia)
  4. Low sodium and high potassium diet
25
Q

What is the DOC for Cushing’s?

A

Mitotane (reduces cortisol)

26
Q

What is the surgical intervention for Cushing’s?

A

Adrenalectomy

27
Q

What is a Pheochromocytoma?

A

Tumor on the adrenal gland, does not affect the adrenal cortex

28
Q

What are the 5 P’s of Hypertensive Crisis?

A
  1. Palpitations
  2. Pressure
  3. Perspiration
  4. Pallor
  5. Pain in the head
29
Q

What is the management of pheochromocytoma?

A
  1. No palpation (may disturb the adrenal gland)
  2. No heating
30
Q

What is the DOC for hypertensive crisis?

A
  1. Hydralazine
  2. Sodium nitroprusside
31
Q

What is the surgical intervention for pheochromocytoma?

A

Adrenalectomy