9. Anti-Inflammatories Flashcards
What is the mechanism of action of NSAIDs?
Inhibit COX to prevent arachiodonic acid being converted to prostaglandins
What are the effects of NSAIDs?
Anti-inflammatory
Analgesic
Anti-pyretic
Why can NSAIDs cause bleeding?
Inhibition of COX in platelets
This is used by giving aspirin to prevent heart attacks
Why can NSAIDs cause gastric ulceration?
Inhibition of COX in the stomach, where it normally maintains the mucous membrane
Why can COX 2 inhibitors not be given as blood thinners?
COX 2 is present on inflammatory cells, COX 1 on platelets and gastric mucosa
Therefore COX 2 inhibitors don’t cause gastric ulceration
What is the mechanism of action of zileuton?
Inhibits leucotriene synthesis
What is the MOA of montelukast?
Inhibits leucotriene receptor
Used in asthma
What is the MOA of glucocorticoids?
Reduce production of IL-1, 2, IFN, prostaglandins, leucotrienes
What side effect is associated with glucocorticoids?
Lowers numbers of all immune cells except neutrophils
What is the MOA of sulfasalasine?
Reduces IL-1 to inhibit T cell replication
Used in infective polyarthritis
What is hydroxychlorine?
Anti-malarial useful in inflammatory arthritis
What non-DMARD drugs are used in RA?
NSAIDs, low dose prednisone, steroids for flares
What are the options for disease altering treatment of RA?
Methotrexate
DMARDs
DMARD and anti-TNF
What does DMARD stand for?
Disease Modifying Anti-Rheumatic Drugs
What is gout?
Uric acid crystals are deposited in the joints
