15. Cytokine Targeted Therapy Flashcards
What diseases is recombinant IL-2 used in?
Renal cell carcinoma
Metastatic melanoma
Name 3 IL-2 targeted therapies
Cyclosporine
Tacrolimus
Sirolimus
What is the benefit of cyclosporine over a cytotoxic agent?
Cyclosporine inhibits antibody production against T-cell dependent antigens but not T-cell independent ones
This means organs won’t be rejected but the patient still has a functioning immune system
What is the other name for tacrolimus?
FK506
How do cyclosporine and tacrolimus work?
Inhibit gene transcription of IL-2 and other CKs
- Bind to intracellular receptors called immunophilins
- Drug and receptor bind to calcineurin and reduce production of IL-2
What receptor does cyclosporine bind to?
Cyclophilin
What receptor does tacrolimus bind to?
FKBP
What is the substrate of calcineurin?
NFAT
What is the other name of sirolimus?
Rapamycin
What is the MOA of rapamycin?
Binds to FKBP
Inhibits mTOR to stop signalling cascade
What are the uses of sirolimus?
Immunosuppression in organ transplant and AI
Coated stents
Renal cell carcinoma, melanoma and breast cancer
Which IL-2 treatments are used together synergistically in transplant treatment?
Sirolimus and cyclosporin
How is TNF targeted?
Directly by the fusion of a soluble TNF receptor and the Fc portion of an antibody
Name 2 anti-TNF drugs
Etanercept
Infliximab
What diseases are anti-TNFs used to treat?
RA
Anti-TNFa in Crohn’s and ulcerative colitis
