83 - Obesity and Lifestyle Choices

Question 1

Amount of time taken for an adipocyte to die

Answer 1

~6 months of reduced energy diet

Question 2

Part of brain stimulated by leptin

Answer 2

Arcuate nucleus of hypothalamus

Question 3

Effect of leptin stimulation of hypothalamic arcuate nucleus

Answer 3

POMC and CART release from hypothalamus, which suppress appetite.

Question 4

Things released by hypothalamic arcuate nucleus that increase appetite

Answer 4

Neuropeptide Y and agouti-related peptide

Question 5

Leptin levels of many obese people

Answer 5

High leptin levels.

Leptin receptor not functioning properly leads to lack of leptin appetite suppression.

Question 6

Role of adiponectin

Answer 6

Stimulates the phosphorylation and activation of AMP-activated protein kinase (AMPK) in skeletal muscle and liver.

This activates fatty-acid oxidation, glucose uptake and lactate production in muscle. Gluconeogenesis decreases in the liver.

Reduces circulating glucose levels

Question 7

Ghrelin role

Answer 7

Stimulate hunger by activating neuropeptide Y neurons in the arcuate nucleus of the hypothalamus.

Question 8

What releases adiponectin?

Answer 8

Adipocytes