6.6 HORMONES, HOMEOSTASIS AND REPRODUCTION Flashcards
ESSENTIAL IDEA
hormones are used when signals need to be widely distributed
ENDOCRINE SYSTEM
a stimulus is received and processed
hormones are secreted directly into the blood
the action of hormone change the condition of the tissue
this change is monitored though feedback
most hormonal change = negative feedback
KEY ENDOCRINE GLANDS 8
pineal gland
pituitary gland
thyroid gland
thymus
adrenal gland
pancreas
ovary
testes
BLOOD GLUCOSE IS MONITORED BY
pancreatic cells
FASTING
reduces blood sugar
BLOOD SUGAR INCREASES
by absorption of glucose from digestion in the intestine
EXAMPLE OF NEGATIVE FEEDBACK
glucoregulation
GLUCOREGULATION USES
negative feedback
hormones insulin/glucagon
IF BLOOD GLUCOSE IS TOO TOO HIGH
B cells of pancreas produce insulin
insulin stimulates uptake of glucose to cells
insulin stimulates liver/ fat cells to store glucose as glycogen
lead to decrease in blood glucose
IF BLOOD GLUCOSE IS TOO LOW
alpha cells of pancreas produce glucagon
glucagon stimulates liver to break down glycogen into glucose
leads to increase blood sugar
TYPE 1 DIABETES
early onset
hereditary, weak relationship
trigger needed: illness
beta cells destroyed
insulin production stops
TYPE II DIABETES
adult onset
hereditary, strong relationship
related to obesity and poor diet
fewer insulin receptors in liver
less sensitivity to insulin
DIABETES
reduced ability to control blood glucose through insulin
THYROXIN SOURCE
thyroid gland
THYROXIN TARGETS
most body cells
THYROXIN EFFECTS
increases metabolic rate/ rate of protein synthesis
increases heat production/ increased respiration
LEPTIN TREATMENT FOR OBESITY
EXPERIMENT ON MICE
obese mice possess two recessive alleles and consequently do not produce any leptin
obese mice treated with leptin saw large weight loss
LEPTIN TREATMENT FOR OBESITY
HUMAN FAILURE
most people have naturally high levels of leptin
if linked to leptin obesity in people is due to resistance of the appetite control to leptin
very few patients in the clinical trial experienced weight loss
many patients experienced side-effects such as skin irritations
SRY GENE
gene on the Y chromosome causes embryonic gonads to develop into testes and secrete testosterone
TESTOSTERONE
secreted by testes
causes genitalia to develop
TESTES
develop from the embryonic gonads when the embryo is becoming a fetus
TESTOSTERONE AT PUBERTY
primary sexual characteristics of sperm production in the testes
development of secondary sexual characteristics
enlargement of penis
growth of pubic hair
deepening of the voice
ESTROGEN AND PROGESTERONE
cause pre-natal development of female reproductive organs and female sexual secondary characteristics during puberty
ESTROGEN AND PROGESTERONE SOURCE
at first by mother’s ovaries and then her placenta
ESTROGEN AND PROGESTERONE
PUBERTY
primary sexual characteristic of egg release
dev of female secondary sexual characteristics
enlargement of breast
growth of pubic hair
FEMALE REPRODUCTIVE SYSTEM DIAGRAM
https://image.slidesharecdn.com/biok6-160317032544/95/bioknowledgy-presentation-on-66-hormones-homeostasis-and-reproduction-19-638.jpg?cb=1458201378
MALE REPRODUCTIVE SYSTEM DIAGRAM
https://image.slidesharecdn.com/biok6-160317032544/95/bioknowledgy-presentation-on-66-hormones-homeostasis-and-reproduction-21-638.jpg?cb=1458201378
MENSTRUAL CYCLE
controlled by endocrine system
FSH
pituitary
stimulates oocyte dev
LH
pituitary
matures oocytes and causes release
ovulation
ESTROGEN
ovaries
dev of endomentrium
early: +ve feedback on FSH
late: -ve feedback on FSH and LH
PROGESTERONE
ovaries
maintains endometrium
-ve feedback on FSH and LH
OCOCYTE
cell in ovary
HCG
pregnancy hormone
keeps estrogen and progesterone high
OXYTOCIN
birth hormone:
contractions of uterus
MENSTRUAL CYCLE DAY 1-4
follicular phase
menstruation
endometrium sheds
FSH increases
stimulating follicle dev
MENSTRUAL CYCLE DAY 5-14
ovulatory phase
FSH and follicle stimulate oestrogen release
oestrogen stimulates endometrium dev
oestrogen stimulate LH
peak in LH causes ovulation (day 14)
MENSTRUAL CYCLE DAY 14-28
luteal phases
fall in LH
corpus luteum forms from now empty follicle
corpus luteum releases progesterone
progesterone maintains the endometrium and inhibits FSH and LH
IF NO FERTILISATION AND IMPLANTATION OCCURS
progesterone and oestrogen drop
triggering menstruation and FSH release
MENSTRUAL CYCLE IS CONTROLLED BY
negative feedback
endocrine system
with ovarian and pituitary hormones
MENSTRUAL CYCLE DIAGRAM
https://image.slidesharecdn.com/biok6-160317032544/95/bioknowledgy-presentation-on-66-hormones-homeostasis-and-reproduction-26-638.jpg?cb=1458201378
EXPLAIN THE ROLE OF HORMONES IN THE REGULATION OF THE MENSTRUAL CYCLE
FSH and LH are produced by the pituitary gland
estrogen and progesterone are produced by the ovary
FSH stimulates the ovary to promote dev of a follicle
the dev follicles secrete estrogen, which inhibits FSH (-ve feedback)
estrogen stimulates growth of endometrium
estrogen stimulates LH secretion (+ve feedback)
LH stimulates follicle to grow and triggers ovulation
follicle becomes corpus luteum
the corpus luteum secretes estrogen and progesterone
estrogen and progesterone maintain the endometrium
estrogen and progesterone inhibit LH and FSH (-ve)
after two weeks the corpus luteum degenerates
progesterone and estrogen levels fall
triggers menstrual bleeding
pituitary gland secretes FSH and LH, as they are no longer inhibited
menstrual cycle continues
MELATONIN
controls circadian rhythm
LEPTIN
inhibits appetite
IN VITRO FERTILISATION
DOWN REGULATION
first step
shutting down menstrual cycle
stopping secretion of pituitary/ ovarian hormones
done with a drug
IN VITRO FERTILISATION
SUPER OVULATION
2nd step
collects multiple eggs from the woman
high dose of FSH are injected
to stimulated dev of multiple follicles
injection of HCG when follicles reach a certain size
maturation process starts
IN VITRO FERTILISATION
STEP 3
prepared eggs are combined with sperm in sterile conditions
successful fertilized eggs are then incubated before implantation
IN VITRO FERTILISATION
STEP 4
two weeks before implantation woman takes progesterone to aid implantation
this is continued until pregnancy test
and if positive
until 12 of gestation
WILLIAM HARVEY
investigation in sexual reproduction in deers
menstrual blood did not contribute to the formation of a fetus