6. HTA Flashcards

1
Q

population in which to suspect 2nd hyperTA (eg given in objective) (3)

A

young patients requiring multiple medications,

patients with an abdominal bruit,

patients with hypokalemia in the absence of diuretics

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2
Q

Definition hypertensive urgency

A

dBP≥130mmHg

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3
Q

definition hypertensive emergency

A

Severe elevation of BP (no cut off)

AND presence of any of these sx manifesting target organ damage

CNS
headache,
dizziness,
altered mental status,
changes in vision

CARDIO/resp
SOB, CP
Vo

Acute renal failure
decreased urine output

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4
Q

Target organ damage

A

Cerebrovascular
- Hypertensive encephalopathy (mental status change)
- Intracranial hemorrhage (stroke)
- vascular dementia

Hypertensive retinopathy

Cardiac
- Acute aortic dissection
- Acute LV failure: dysfunction / chronic hypertrophy
- Acute coronary syndrome

Renal
- Acute kidney injury
- CKD - albuminuria

PAD (claudication)

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5
Q

Visit 1 BP measurement, gold standard, how many readings

A

Min 3 readings
(discard first reading)

gold standard is automated office blood pressure (AOBP)

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6
Q

When to perform out of office BP

A

If AOBP (office) ≥ 135/85

or non-AOBP ≥ 140/90,

out-of-office BP should be performed before Visit 2

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7
Q

Hypertension diagnosis out of office

A

1) Daytime ambulatory BP ≥ 135/85

2) 24h ambulatory BP (ABPM) ≥ 130/80

3) Daytime home BP (7d) ≥ 135/85

2 readings before breakfast, 2 readings 2h after dinner, eliminate day 1 readings and average other 6 days (total 24 readings)

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8
Q

Visit 2 mean OBPM HTA diagnosis

A

≥140/90 with
macrovascular target organ damage,
diabetes mellitus or
CKD (eGFR<60)

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9
Q

VIsit 3 mean OBPM HTA diagnosis

A

Mean OBPM ≥160/100

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10
Q

VIsit 4-5

A

Mean OBPM ≥140/90

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11
Q

Accurate BP Measurement - things to not forget (4 categories)

A

Cuff with appropriate bladder size (Bladder width 40% of arm circumference and length 80-100% of arm circumference)

Nondominant arm, unless SBP difference >10mmHg (use higher value arm)

Rest comfortably for 5 minutes in seated position, back support, arm supported at heart level

No caffeine/tobacco 1h, no exercise 30mins preceding

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12
Q

take BP in children above what age

A

3 yo

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13
Q

whn to diagnose HTA in children or ado (how many readings)

A

auscultatory-confirmed BP readings ≥95th percentile at 3 different visits

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14
Q

target organ dammage

A

Cerebrovascular

Stroke

Dementia (Vascular)

Hypertensive retinopathy

Cardiac

LV dysfunction

LV hypertrophy

CHF

CAD (MI, angina, ACS)

Renal (CKD, albuminuria)

PAD (claudication)

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15
Q

Target TA in db pt

A

Diabetes <130/80

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16
Q

Target TA

All (including elderly)

A

<140/90

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17
Q

Target TA SPRINT

A

SPRINT population ≥ 50yo

CV disease

CKD

FRS ≥15%

Age ≥75yo

18
Q

HTA follow up global risk (11 ish)

A

Assess global cardiovasc risk

Age ≥55yo

Male

Family Hx CAD (Age <55 in men, <65 in women)

Sedentary lifestyle

Poor dietary habits

Abdominal obesity

Dysglycemia

Smoking

Dyslipidemia

Stress

Nonadherence

19
Q

HTA labs (5)

A

FBG and/or HbA1C

Lipid profile (serum total cholesterol, LDL, HDL, non-HDL, TG) fasting or non-fasting

K, Na, Cr

UA (r/o albuminuria which would guide treatment, eg ACEi/ARB)

EKG

20
Q

Adjusting antihypertensive drug therapy

A

q1-2 months

21
Q

Modify health behaviours q 3-6 mo

A

exercise
weight loss
ROH
tobacco cessation
Diet - DASH/ Mediterranean
Sodium <2000mg (1 tsp salt) per day
Potassium increase dietary intake to reduce BP (if no risk of hyperkalemia)

stress mgmt

22
Q

R/A rx (R/O obvious rx that can increase BP/ should not be taken when increased BP)

A

NSAIDs
Contraceptives
steroids,
licorice
some OTC meds

23
Q

When to suspect RENOVASCULAR

secondary hyperTA

A

Sudden onset, worsening HTN and age >55 or <30*

Abdominal bruit*

HTN resistant to ≥3 drugs*

Serum creatinine ≥30% increase with ACE-I or ARB

Atherosclerotic vascular disease (smoke/DLP)

Recurrent pulmonary edema with hypertensive surges

24
Q

what rare disease could cause HTA and which pop expecially

A

younger women and accounting for 10% to 20% of the cases of renal artery stenosis

Consider r/o fibromuscular dysplasia if you think about 2ndary hyperTA

+ unexplained asymmetry of kidney sizes (>1.5cm)

25
2 big categories of secondary hyperTA
renovascular hypertension endocrine hypertension
26
endocrine hypertension - 2 big causes
1) Hyperaldosteronism 2) Pheochromocytoma/paraganglioma
27
Hyperaldosteronism - investigations
Plasma aldosterone and renin/renin activity
28
Pheochromocytoma/paraganglioma - investigations
24h urinary total metanephrines and catecholamines or 24h urine fractionated metanephrines, plasma free metanephrine/normetanephrines)
29
What makes you suspect Hyperaldosteronism (3)
K<3.5mmol/L or marked diuretic-induced hypokalemia (K<3) HTN resistant to ≥3 drugs Incidental adrenal adenoma
30
What makes you suspect Pheochromocytoma/paraganglioma (5)
Paroxysmal, unexplained, labile, severe (≥180/110) HTN refractory to usual therapy Symptoms of catecholamine excess (headache, palpitations, sweating, panic attacks, pallor) HTN triggered by BB, MAO-i, micturition, changes in abdominal pressure, surgery, anesthesia Incidental adrenal mass Hereditary (MEN2A/B, neurofibromatosis type 1, Von Hippel-Lindau)
31
what is Pheochromocytoma
rare tumor of the adrenal medulla that causes excess secretion of catecholamines (epinephrine and norepinephrine)
32
what is Hyperaldosteronism
Excess production of aldosterone, a hormone produced by the adrenal cortex that regulates sodium and potassium balance
33
Type of meds that exist for BP control
ACE-i (nonblack) or ARB Long-acting CCB (eg. Amlodipine) Long-acting Thiazide diuretic (eg. Chlorthalidone, indapamide) BB (<60yo)
34
Rx for blood control to AVOID in black ppl
ACE-I !!! 11% increase in CVA events
35
Examples of ACE i
perindopril ramipril
36
Examples of ARB / ARA
Candesartan (Atacand) Irbesartan (Avapro) Losartan valsartan
37
règle de 10-5 pour les rx de TA
on peut débuter 1 classe de Rx PAR 10mmHg au-dessus de la cible syst 5mm Hg au-dessu cible diast initier 2 rx cpmme premier tx si cible est >20/10
38
examples rx combinés
39
effets secondaires CCB amlodipine à surveiller
40
effets secondaires ACE i à surveiller
41
effets secondaires ARB à surveiller