Sketchy - Cell Wall and Membrane Active Antibiotics - Ampicillin, Amoxicillin, Piperacillin, Ticarcillin

Question 1

Class:

Ampicillin (IV, PO); amoxicillin (PO)

Answer 1

Aminopenicillins - Beta-lactams

Question 2

Class:

Piperacillin (IV); Ticarcillin

Answer 2

Extended spectrum penicillin - Beta-lactams

Question 3

T/F: Ampicillin, Amoxicillin, Piperacillin, Ticarcillin are bacteriocidal.

Answer 3

True

Question 4

Ampicillin and Amoxicillin may be used against gram positive organisms (Staph and Strep) in addition to:

Answer 4

Gram negative - Ampicillin and Amoxicillin have improved ability to penetrate the gram negative cell wall membrane

Considered “broad spectrum”

Question 5

Which Aminopenicillin has better oral absorption?

Answer 5

Amoxicillin

Question 6

What is an appropriate treatment for streptococcal pharyingitis caused by Strep pyogenes?

Answer 6

Ampicillin, Amoxicillin

Question 7

Amoxicillin is effective against otitis media and sinusitis caused by what organisms?

Answer 7

Strep pneumo;
Haemophilus influenzae;
Moraxella catarrhalis

Can also use Ampicillin and Amoxicillin against pneumonia caused by Strep pneumo; Haemophilus influenzae;

Question 8

Amoxicillin is part of the triple therapy for what infection?

Answer 8

H. Pylori

with Clarithromycin and a PPI

Question 9

Early stage Lyme disease, or Lyme disease in young children, can effectively be treated with what penicillin-type drug?

Answer 9

Amoxicillin (an aminopenicillin)

Question 10

IV Ampicillin is recommended for:

Answer 10

Anaerobic infections such as aspiration pneumonia

Question 11

Ampicillin is appropriate for treating Enterococcus, a gram positive bug that causes:

Answer 11

UTIs;
Endocarditis

Ampicillin resistant strains due to beta-lactamase production

Question 12

Use Ampicillin to treat what bug responsible for meningitis in newborns and the elderly?

Answer 12

Listeria

Question 13

Can you use the aminopenicillins (ampicillin, amoxicillin) for GIs and UTIs caused by gram negative rods?

Answer 13

Yes

They are effective against. E. Coli

Question 14

Are aminopenicillins beta-lactamase resistant or sensitive?

Answer 14

Sensitive

Add clavulanate to become beta-lactamase resistant

Question 15

Class:
Tazobactam
Sulbactam

Answer 15

Beta-lactamase inhibitors;

Add to Aminopenicillins

Question 16

Asplenic patients are at higher risk of infection by encapsulated bacteria. What are two of the more common bacteria they are at risk for?

Answer 16

Haemophilus influenzae

Strep pneumoniae

Question 17

What prophylaxis is indicated in patients at risk for endocarditis who undergo dental procedures?

Answer 17

Amoxicillin

Question 18

Adverse effects: Aminopenicillins (Ampicillin, Amoxicillin)

Answer 18

Rash, can progress to SJS;

Skin rashes if given to a patient with mono (EBV)

Question 19

Adverse effects: Amoxicillin-clavulanate

Answer 19

Liver injury

Question 20

Piperacillin-tazobactam extends coverage from gram positives to what important bacterial class?

Answer 20

Anaerobes ie Pseudomonas

Question 21

Ticarcillin-clavulanate extends coverage from gram positives to what important bacterial class?

Answer 21

Anaerobes ie Pseudomonas