3.1.3 Neisseria meningitidis

Question 1

N. meningitidis is a commensal carrier in what part of the body?

Answer 1

Nasopharyngeal and oropharyngeal

Question 2

What are the virulence factor for N. meningitidis?

Answer 2

Pili
Polysaccharide capsule
- Encapsulated strains/serogroups: 13
- A, B, C, Y, W-13
- A (Pandemics)
- B (Community acquired)
- Y (pneumonia)
- W-13 (Invasive species)

Outer membrane proteins
LOS Endotoxin
IgA1 protease

Question 3

What are the 5 encapsulated strains of meningitidis that can cause infection?

Answer 3

A - Pandemic
B - Community acquired
Y - Pneumococcal pneumonia
W-135 - Invasive disease

Question 4

A clinical infection that is characterized by abrupt onset of frontal headache and stiff neck?

Answer 4

Epidemic meningitis

Question 5

N. meningitidis is known to cause what disease?

Answer 5

meningitis
meningococcemia

Question 6

What do you call a N. meningitidis in blood?

Answer 6

Meningococcemia

Question 7

Inflammation on the meninges called?

Answer 7

Meningitis

Question 8

What is the mode of transmission for endemic and epidemic meningitis?

Answer 8

Air droplet

Question 9

What hospital is being catered for patients with meningococcemia

Answer 9

San Lazaro Hospital

Question 10

Meningococcemia is characterized by?

Answer 10

Purpura and petechial rash

Question 11

Hemorrhage in the skin and mucous membrane producing bruises

Answer 11

Purpura

Question 12

A pinpoint red spots caused by the hemorrhage?

Answer 12

Petechial rash

Question 13

Severe bacterial infection which causes hypotension which can lead to DIC

Answer 13

Tachycardia and Hypotension

Question 14

Destruction of blood vessel

Answer 14

DIC

Question 15

A severe type of meningococcemia that has hemorrhage in adrenal glands

Answer 15

Waterhouse-Friderichsen syndrome