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Bacte Lec (Overview) [Prelims 1] > 3.1.2 Neisseria gonorrhoeae > Flashcards

3.1.2 Neisseria gonorrhoeae Flashcards

1
Q

What are the virulence factor of N. gonorrhoeae?

A

Receptors to human transferrin

Outer membrane proteins
- Protein I (porB)
- Protein II (Opacity)
- Protein III (Reduction modified protein)

Pili

Capsule

Lipooligosaccharide (Endotoxins)

IgA protease

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2
Q

This virulence factor binds to iron-carrying protein to steal the iron

A

Receptors for human transferrin

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3
Q

What are the outer membrane protein for Neisseria gonorrhoeae?

A

Protein I (porB)
Protein II (Opacity)
Protein III (Reduction modified protein)

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4
Q

What are the genes for protein I in outer membrane that is being secreted by Neisseria meningitidis?

A

porA and porB

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5
Q

An outer membrane proteins that is a protective against inflammation and serum complement mediated killing

A

Protein I (porB)

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6
Q

What is membrane attack complex? (MAC)

A

IT is where the complement attacks or kills the infected cells that has infected by bacteria

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7
Q

An outer membrane protein that adheres to phagocytic and epithelial cells

A

Protein II (Opacity)

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8
Q

An outer membrane that blocks host serum bactericidal IgG

(Block phagocytosis and response to lymphocytes which prevents in the production of antibodies)

A

Protein III (Reduction modified protein)

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9
Q

How do you connect each outer membrane protein?

A

Protein II (Opacity) allows adherence of the bacteria to the phagocytes and the epithelial cell then the Protein I (porB) gene prevents MAC and inflammation which assist the Protein III (Reduced modified protein) to block phagocytosis and bactericidal and immune response leading to no production of antibodies

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10
Q

What is the specific nutrient or growth requirement of N. gonorrhoeae?

A

Iron

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11
Q

Pili has 5 distinct colony types?

A

T1 and T2 = Virulent
T3-T5 = no pili (Not virulent)

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12
Q

What is the function of pili

A

attachment to host
Prevents phagocytosis
exchange genetic material

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13
Q

Outer membrane proteins that create a channel for nutrients to pass into and waste products to exit cell

A

Protein I (porB)

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14
Q

What is the function of capsule in N. gonorrhoeae

A

Prevents phagocytosis

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15
Q

A virulence factor that mediates damage to body tissue and releases a outer membrane fragment (blebs)

A

Lipooligosaccharides or endotoxins

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16
Q

What is the main vivo virulence factor of N. gonorrhoeae?

A

Lipooligosacchrides

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17
Q

What is IgA protease?

A

Cleaves IgA mucosal surfaces

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18
Q

What bacteria is the most sexually acquired from asymptomatic carriers

A

N. gonorrhoeae

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19
Q

If female has N. gonorrhoeae?

A

Infection carrier

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20
Q

If male has N. gonorrhoeae

A

Symptoms

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21
Q

What are the clinical infections for N. gonorrhoeae?

A

Gonococcal urethritis and cervicitis

Conjunctivitis (Ophthalmia neonatorum)

Gonorrhea

Perihepatitis (Fitz-Hugh-Curtis syndrome)

Disseminated gonococcal disease

Extragenital infections
- pharyngitis
- Anorectal infections

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22
Q

What is the meaning of Gonorrhea?

A

Flow of seed
Clap from french word

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23
Q

Untreated Gonococcal urethritis and Cervicitis will lead to?

A

PID (Pelvic inflammatory disease

Sterility

Ectopic pregnancy

Fitz-Hugh-Curtis syndrome

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24
Q

A vertically transmitted disease that can lead to blindness of a child or newborn

A

Conjunctivitis (Ophthalmia neonatorum)

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25
Q

Gonorrhea is a acute pyogenic infection of the?

A

Pharynx
Urogenital tract
Conjunctiva of the eye

(PUC)

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26
Q

In male, what is the incubation period of gonorrhea?

A

2-7 days

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27
Q

In male, what is the MOT of gonorrhea?

A

Sexual contact

28
Q

What is the meaning of Acute pyogenic infection?

A

Presence of pus formation

29
Q

What bacteria is One of the leading cause of STD?

A

Chlamydia trachomatis

30
Q

What are other bacteria/virus cause STD?

A

N. gonorrhoeae
Chlamydia trachomatis

human papilloma virus

31
Q

What are the symptoms of gonorrhea in males?

32
Q

A painful and difficult urination due to urinal discharge

33
Q

What are the complication of dysuria?

A

Epididymitis
Urethral stricture
Prostatitis
infertility

(EUPI)

34
Q

A complication of gonorrhea where an inflammation of small coiled tube of testicles

A

Epididymitis

35
Q

A complication of gonorrhea where a narrowing of urethra

A

Urethral stricture

36
Q

A complication of gonorrhea where inflammation of prostate

A

Prostatitis

37
Q

Females has many as 50% asymptomatic (carriers)

38
Q

What are the symptoms of gonorrhea in females?

A

Dysuria
Cervical discharge
Lower abdominal pain

39
Q

What are the complication in females with gonorrhea?

A

PID which leads to
- Sterility
- Ectopic pregnancy
- Fitz-Hugh-Curtis syndrome

40
Q

What is PID

A

an infection in 1 or more upper female reproductive organs

41
Q

What is the most common site of infection in gonorrhea in females?

A

Endocervix

42
Q

It is the inflammation of the Cervix

A

Cervicitis

43
Q

How to detect Cervicitis?

44
Q

A yellowish in color in Cervicitis

A

Vaginal discharge

45
Q

Why does PID lead to Ectopic Pregnancy?

A

Scarring of the fallopian tube

46
Q

A severe chronic inflammation of the liver capsule WITHOUT the involvement of liver parenchyma.

A

Fitz-Hugh-Curtis syndrome

(Perihepatitis)

47
Q

In perihepatitis, where does the adhesion occur?

A

Inbetween Liver capsule and parietal peritoneum

48
Q

How does the infection occur in Perihepatitis

A

Due to scarring of the fallopian tube, bacteria passes through the liver capsule

49
Q

What do you call the adhesion in perihepatitis?

A

Violin String

50
Q

What happens if the fallopian tube is scar?

51
Q

What is the first thing you do if you received a sample with this disease?

A

Gram Staining

52
Q

Example of Disseminated gonococcal disease

A

Blood-borne dissemination

Gonococcal arthritis

53
Q

Majority of DGD/3-5% of men are asymptomatic due to what strains?

A

Arginine
Hypoxanthine
Uracil

54
Q

Blood borne dissemination is not recovered in Blood culture?

55
Q

Blood borne dissemination, N. gonorrhoeae is inhibited by?

A

Sodium polyanethol sulfonate

56
Q

Gonococcal arthritis is also known as

A

Purulent arthritis

57
Q

Gonococcal arthritis is result from?

A

Disseminated gonococcal bacteremia

58
Q

What antimicrobial agent is useful in treating gonorrhea?

A

Penicillin

59
Q

It is an anti-coagulant to prevent the clotting of blood that is being
put in the blood culture bottle.

A

Sodium polyanethol sulfonate

60
Q

What to add in Blood culture if you want to support the growth of N. gonorrhoeae?

61
Q

What is the most common extragenital infections in men having sex with men?

A

Anorectal infections

62
Q

What is the disease of the newborns in Extragenital infection?

A

Ophthalmia neonatorum

63
Q

Inflammation of tonsils?

A

Gonococcal pharyngitis

64
Q

What is use to treat Ophthalmia neonatorum?

A

Erythromycin

65
Q

If Ophthalmia neonatorum is left untreated, it will lead to?

66
Q

What is the mode of transmission for Ophthalmia neonatorum?

A

Vertical transmission

Bacte Lec (Overview) [Prelims 1] (34 decks)

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