11.5- Molecular Second Line Defense Flashcards
What are the three major players in the molecular second line defense?
Cytokins, Iron binding proteins, and compliment proteins.
What do Cytokins do?
Stimulate inflammation Generate Fever Recruit leukocytes to fight infection Stimulate tissue and blood vessel repair Promote leukocyte and lymphatic tissue development Antiviral effects (interferons) Immune system regulation and activation
What do Iron biding proteins do?
Limit availability of free iron to reduce bacterial growth
What do Compliment proteins do?
Stimulate inflammation
Tag targets for elimination
Directly kill target cells
Define opsonization
The tasing of target cells by compliment proteins for elimination
Define cytolysis
Destruction of cells targeted by compliment proteins.
What do chemokins do?
Attract white blood cells to the area of damage- stimulate chemotaxis.
Define hematopoiesis
Stimulation of the production of new white blood cells.
Define apoptosis
Cells death triggered by cells near it that know they are infected.
What is the role of interferons?
The give alarm signals when pathogens and tumor cells are detected. They tell surrounding cells to slow proteins synthesis, perform apoptosis, and activate leukocytes
Define TNF?
Tumor necrosis factor. TNF-a gets lots of attention cause it can stimulate inflammation and kill tumors.
Define siderophores
Organic molecules that steal iron from our iron binding proteins.
What are neutrophils key for fighting?
Bacterial and fungal infections
What does compliment system do? What is it made of?
Made of 30 different proteins. Works in cascade fashion to protect against infectious agents.
What are the three pathways for activation compliment proteins?
Classic pathway
Alternative Pathway
Lectin Pathway
