Wound Healing/tissue repair and chronic inflammation

Question 1

What are Labile cells?

Answer 1

divide and proliferate throughout life

e.g corneal epithelium by corneal stem cells in the limbus.

Question 2

what are stable cells?

Answer 2

divide at a slow rate but when stimulated by growth factors,they significantly increase heir replication rate and divide more rapidly

Question 3

what are permanent cells?

Answer 3

cells cannot divide,cannot go through mitosis

may be capable of cellular repair if necrosis is not initiated.

Question 4

what is proliferation?

Answer 4

cell division by mitosis

Question 5

What is regeneration?

Answer 5

perfect restoration with no scar formation.

Question 6

what is wound repair?

Answer 6

restores normal function and structure.

Question 7

What are the causes of Chronic inflammation?

Answer 7

1) persistent infections
2) immune mediated:autoimmunity
3) prolonged exposure to toxin/foreign object

Question 8

What are the 3 main features of chronic inflammation?

Answer 8

1) active inflammation;plasma cells and more antibodies.
2) Tissue destruction:induced by persistent injurious agent or by inflammatory cells.
3) attempts at repair or healing:connective tissue replacement of damaged tissue