Wk3 Uterine drugs

Question 1

posterior pituitary

induces labor

reduces postpartum bleeding

releases milk

Answer 1

oxytocin

Question 2

3 prostaglandins that induce labor

Answer 2

dinoPROSTone

dinoPROST

misoPROSTol

Question 3

reduces post partum uterine bleeding

NEVER given to induce labor

Answer 3

ergonovine

Question 4

B2 agonist

smooth muscle relaxant

Answer 4

Terbutaline

Question 5

Competes with Ca2+

smooth muscle relaxant?

Answer 5

Mag sulfate

Question 6

oxytocin receptor antagonist

smooth muscle relaxant

Answer 6

Atosiban

Question 7

NSAID that prevents uterine contraction

Answer 7

indomethacin

Question 8

Any dug used to suppress uterine smooth muscle contractions and thereby suppress labor

Answer 8

Tocolytics

Question 9

SM receptor pathway for contraction:

Answer 9

Gq –> PLC –> IP3 –> increased Ca2+

Question 10

SM receptor pathway for relaxation:

Answer 10

Gs –> increased cAMP

Question 11

Oxytocin receptor locations (3):

Answer 11

1. myoepithial cells in mamary glands
2. pregnant myometrium
3. CNS

Question 12

When during pregnancy is oxytocin effective?

Answer 12

third trimester only

**increased receptors

Question 13

Can oxytocin be given orally?

Answer 13

nope

it’s a peptide

Question 14

Drug of choice for labor induction:

Answer 14

oxytocin

Question 15

Oxytocin risks…

Answer 15

slide 16

Question 16

contracts uterus and produces hyperalgesia

Answer 16

PGE2

Question 17

natural PGE

Answer 17

dinoPROSTone

Question 18

synthetic PGE

Answer 18

misoPROSTol

**can be used as abortifacent

Question 19

natural PGF2alpha

Answer 19

dinoPROST

Question 20

PGF2alpha given IM

Answer 20

carboPROST

Question 21

act via alpha adrenergic receptors, dopaminergic, and 5HT2’s

induced contraction –> control post partum bleeding

NOT for induction

Answer 21

ergometrine = ergonovine

Question 22

B2 agonist to prevent contraction:

Answer 22

Terbutaline

Question 23

B2 pathway for SM relaxation

Answer 23

activates AC —> increased cAMP

Question 24

competes with Ca2+ –> relaxes SM

prevent seizures due to eclampsia

Answer 24

Mag sulfate

Question 25

receptor pathway block by oxytocin receptor antagonist: What's the drug?

Answer 25

inhibits IP3 ---> decreased Ca2+ Atosiban **increased fetal mortality

Question 26

short term delay in labor non-selective COX inhibitor

Answer 26

indomethacin

Question 27

Tocolytic summary on

Answer 27

slide 31

Question 28

PGF2a and oxytocin receptor?

Answer 28

Gq **both increase IP3 --> increase Ca2+