Wk1 Adrenal Path Flashcards by Weston Tardy | Brainscape

Q

BBIIG roles or cortisol:

A

Blood pressure

Bone (breaks down)

Inflammation (supresses)

Immune sys (supresses)

Gluconeogenesis (stimulates)

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Q

Most common cause of Cushing Syndrome:

A

Iatrogenic

–exogenous steroids

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Q

labs in Iatrogenic Cushing’s:

A

high cortisol

low ACTH

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Q

Cushing DISEASE

A

pituitary etiology producing too much ACTH

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Q

labs in Cushing DISEASE

A

high cortisol (can suppress with high Dex)

high ACTH

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Q

three causes of adrenal Cushing

A

adenoma

hyperplasia

carcinoma

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Q

labs in adrenal Cushing

A

high cortisol

low ACTH (already suppressed so Dex in non-dx)

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Q

Common cause of paraneoplastic Cushing

A

SCC lung

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Q

Would Dex challenge supress ACTH in SCC?

A

no, not part of axis

“fake ACTH”

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Q

Sx of primary hyperaldosteronism

A

HTN (hypernatremia)

Weakness/fatugue/psychosis (hypokalemia)

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Q

Renin in primary hyperaldosteronism?

A

low

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Q

Cause of secondary hyperaldosteronism?

A

high Renin

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Q

sudden virilization

abd mass

ugly tumor

bad prog

A

adrenocortical carcinoma

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Q

Most common cause of Congenital Adrenal Hyperplasia

A

21-hydroxylase deficiency

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Q

see slide

A

43 – CAH causes

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Q

Autoimmune destruction of adrenal cortex:

A

Addisons

Q

PE findings of Addisons:

A

low BP

skin pigmentation – from too much MSH

Q

Three causes of ACUTE adrenal insufficiency:

A

Addison crisis
Rapid steroid withdrawl
massive adrenal hemmorrhage

Q

Bacterial infx (N. meningitidis)

hypotension/shock

DIC

massive BL adrenal hemmorrhage

RAPIDLY progressive

A

Waterhouse-Friderichsen Syndrome

Q

Secondary Adrenal insufficiency causes:

A

pituitary or hypothalamic

low cortisol

normal aldo – RAAS still intact

Q

Neoplasm of catecholamine producing cells

A

pheochromocytoma

Q

zellballen

A

pheochromocytoma

Q

derived from neural crest cells

common in childhood

A

neuroblastoma

Q

better prog in neuroblastoma

A

hyperdiploid tumor

fewer N-myc

Q

Homer-wright Rosettes

A

neuroblastoma