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Endo/Repro > Wk3 STDs > Flashcards

Wk3 STDs Flashcards

1
Q

Urethritis in male (inflammatory, exudative infection

Ddx:

A

Neiseria gonorrhoeae

Chlamydia trachomatis

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2
Q

Cervicitis

Ddx:

A

Chlamydia trachomatis

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3
Q

Vaginitis Ddx:

A

T. vaginalis

C. albicans

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4
Q

Vaginosis Ddx:

A

Gardnerella

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5
Q

HPV

genome?

capsid?

envelopment?

A

dsDNA group I

circular genome

Icosahedral

Nonenveloped

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6
Q

Cancer causing factor in HPV:

A

episome E6 –> decreased p53 –> accumulation of mutations

episome E7 –> knocks out Rb

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7
Q

typically purulent discharge in male:

A

Neisseria gonorrhea

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8
Q

typically clear discharge in male:

A

Chlamydia trachomatis

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9
Q

N. gonorrhoeae virulence factors

A

pilli – prevents phagocytosis

endotoxin

capsule

IgA protease

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10
Q

Thayer Martin media

A

N. gonorrhoeae

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11
Q

Glucose oxidizer

A

N. gonorrhoeae

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12
Q

G -

dipplococci

oxidase +

A

N. gonorrhoeae

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13
Q

Tx for N. gonorrhoeae

A

ceftriaxone

+ doxy for probable concurrent Chlamydia

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14
Q

Prophylaxis in neonates from N. gonorrhoeae mother

A

erythromycin eye drops

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15
Q

N. gonorrhoeae

gram ?

A

Gram -

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16
Q

N. gonorrhoea

Oxidase ?

A

oxidase +

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17
Q

Complications of untreated N. gonorrhoeae:

A

PID

ectopic pregnancy

sterility

Fitz-Hugh-Curtis syndrome

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18
Q

LIver infx from N. gonorrhoeae

A

Fitz Hugh Curtis synd

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19
Q

most common cause of septic arthritis in sexually active people

A

N. gonorrhoeae

20
Q

Prevents lasting immunity after N. gonorrhoeae infx:

A

antigenic variation

21
Q

Painful penile ulcers in men:

A

HSV – small blisters

Chanchroid (Haemohylus ducryei) – ugly red

22
Q

Syphilis real name:

A

T. pallidum

23
Q

Painless ulcers

A

T. pallidum

24
Q

Alpha herpes viruses (HSV 1/2)

genome?

capsid?

envelopment?

A

dsDNA group I

LInear genome

Icosahedral

Enveloped

25
Immune control of HSV
cell mediated
26
Tzank smear with giant multinucleated cells:
HSV
27
Tzank smear without multinucleated giant cells:
H. ducryei --- aka Chanchroid
28
Cowdry bodies type A
HSV
29
Tx for HSV
acyclovir
30
MOA for acyclovir
activated by viral thymidine kinase chain terminator selective toxicity for active viral infx
31
3 likely causes of vaginal (NOT urethral) discharge
1. Gardnerella -- white/grey, SMELLY 2. Candida albicans -- itchy, white, small clumps 3. Trichomonas vaginalis -- itchy, yellowish, large amount
32
fishy odor
bacterial vaginosis Gardnerella
33
clue cells
bacterial vaginosis
34
flagellated protozoan
Trichomonas
35
Tx for trichomoniasis
metronidazole
36
Most common cause of vaginitis
C. albicans "yeast infection"
37
Indication that C. albicans is growing rapidly
pseudohyphae
38
Mech of disease for C. albicans
opportunistic ie. post abx
39
1. What cell types does HIV infect, and why does this have such an impact on the patient’s immune response? 2. How does the virus replicate? 3. To what other opportunistic infections is this woman susceptible? 4. What are the risk factors for infection? 5. How can the infection be treated?
Can infect T cells and macrophages. Need CD4, CXCR4, or CCR5. Reverse transcription. Many, list some… Unprotected sexual intercourse, contaminated blood. HAART. NNRTI + 2 NRTI or PI + 2 NRTI.
40
rash on palms and soles of feet
T. pallidum
41
hard chancre at site of pathogen entry
T. pallidum
42
systemic invasion diffuse rash hair falls out 3 weeks - 6 mo after infx
Secondary syphilis
43
latent period up to 20 years
tertiary syphilis
44
gummas
tertiary syphillis
45
gram - spirochete
T. pallidum
46
Host antigen that has antibodies indicative of syphilis
cardiolipin
47
Tx for syphilis
Penicillin G

Endo/Repro (46 decks)

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