Wk1 Thyroid Path Flashcards
High T4
Low TSH
primary hypERthyroidism
High T4
High TSH
secondary or tertiary hypERthyroidism
Low T4
High TSH
primary hypOthyroidism
low T4
low TSH
secondary or tertiary hypOthyroidism
normal T4
low TSH
subclinical hypERthyroidism
**TSH changes before T4 – think of the seesaw with fulcrum closer to T4
normal T4
high TSH
subclinical hypOthyroidism
**TSH changes before T4
anti-peroxidase Ab is likely:
Hashimoto’s thyroiditis
anti-TSH Ab is likely:
Grave’s disease
Most common cause of hyperthyroidism:
Graves disease
Myedema association:
hypOthyroidism
Painless
BIG thyroid
F»M
hypOthyroid
Hashimoto
TFT findings in Hashimoto:
low T4
high TSH
lymphoid follicles
Hashimoto
Hurthle cells
Hashimoto
Cells that mediate Hashimoto
T-cells (CD8’s)
Acute onset
BIG, SORE thyroid
recent URI
ealry hyperthyroid
self-limiting
DeQuervain
granulomatous
multinucleated giant cells
DeQuervain
Painless, slightly enlarged thyroid
post-partum
mild hyperthyroid
Silent thyroiditis
Rock hard neck mass “Woody”
hypOthyroid
tracheal compression
Reidel
fibrosing thyroiditis
hyperthyroid
ophthalmopathy
dermatopathy
Graves
TFT findings in Graves
high T4
low TSH
papillae and scalloped colloid
Graves
Pathogenesis of Graves:
anti-TSH receptor antibodies that are STIMULATORY
**follicular cell proliferation –> big thyroid
**TH release –> hyperthyroid sx
big thyroid gland
Goiter
