Wk3 Anti-neoplastic Hormones

Question 1

Goserelin

Answer 1

GnRH receptor agonist

inhibits FSH/LH secretion AFTER initial spike

combine with steroid inhibitor

Question 2

Degarelix

Answer 2

GnRH receptor ANtagonist

inhibits FSH/LH release

Question 3

Finasteride

Answer 3

5-a-reductase inhibitor

inhibits conversion of testosterone –> DHT

Question 4

Abiraterone acetate

Answer 4

17-a-hydroxylase inhibitor

prevent testosterone synthesis

Question 5

Bicalutamide

Answer 5

testosterone receptor antagonist

Question 6

Flutamide

Answer 6

testosterone receptor antagonist

Question 7

Oxandralone

Answer 7

DHT receptor agonist

**not used for prostate cancer – would make it worse

Question 8

Typical tx for prostate CA:

Answer 8

GnRH agonist + testosterone receptor blocker

goserelin or leuprolide + bicalutamide

Question 9

Leuprolide

Answer 9

GnRH receptor agonist

Question 10

typical Breast CA regimen

Answer 10

standard chemo –> GrRH modulator –> aromatse inhibitor –> estrogen receptor modulator

Question 11

Anastrazole

Answer 11

aromatase inhibitor

Question 12

Exemestane

Answer 12

irreversible aromatase inhibitor

Question 13

Tamoxifen

Answer 13

estrogen receptor modulator

antagonizes receptor in breast

**stimulate it in ovary –> inc. risk of ovarian CA

Question 14

Raloxifene

Answer 14

Estrogen antagonist in breast

and uterus

Question 15

Fulvestrant

Answer 15

Universal estrogen receptor blocker

Question 16

Positive side effects of tamoxifen and raloxifene

Answer 16

stimulate estrogen receptors in bone combating osteoporosis

Question 17

Why is synergism good?

Answer 17

lower doses of multiple drugs reduces toxicity