Wk3 Female Repro Drugs

Question 1

Drug used to stimulate FSH secretion by blocking estrogen receptors:

Answer 1

clomiphine citrate

Question 2

MOA of clomiphine citrate:

Answer 2

estrogen receptor antagonist

block negative feedback

***increasing GnRH, LH, FSH release

Question 3

menotropin

Answer 3

FSH/LH analog

Question 4

urofolitropin

Answer 4

FSH/LH analog

Question 5

used to stimulate induction of ovulation by acting like LH

Answer 5

hCG

Question 6

Synthetic GnRH analog (agonist)

Answer 6

Leuprolide

Question 7

What happens INITIALLY if a NONpulsatile dose of Leuprolide is administered?

Answer 7

transient RISE in FSH/LH

followed by decrease

Question 8

What happens with pulsatile administration of Leuprolide?

Answer 8

increases FSH/LH –> follicle development

Question 9

GnRH ANtagonists:

Answer 9

ganiRELIX

cetroRELIX

Question 10

Pure estrogen antagonist in all tissue

Answer 10

Fulvestrant

Question 11

NONsteroidal

Reversible

Aromatase inhibitors

Answer 11

anasTROZOLE

leTROZOLE

Question 12

Steroidal

NONreversible

Aromatase inhibitor

Answer 12

Exemestane

Question 13

Main idea with aromatase inhibitors:

Answer 13

prevent estrogen production

used in estrogen+ cancers

Question 14

Progestin analog for contraception

Answer 14

Medroxyprogesterone acetate

Question 15

estrane analog for contraception

progesterone receptor agonist

Answer 15

Norethindrone

Question 16

gonane analog for contraception

progesterone receptor agonist

Answer 16

Levonorgestrel

Question 17

Progesterone agonist used as emergency contraceptive

cannot terminate pregnancy

Answer 17

Levonogestrel (Plan B)

Question 18

Selective Progesterone Receptor antagonist used to prevent ovulation (low dose) or terminate early pregnancy (high doses with misoprostol)

Answer 18

Mifepristone

Question 19

PGE1 analog

Answer 19

misoprostol

Question 20

Progesterone ANtagonist for emergency contraception

prevents or delays ovulation

Answer 20

Ulipristal acetate