Weight Loss Flashcards
drugs that cause weight loss/gain, OTC, Rx, Bariatric Surg, counseling
what drugs/conditions cause weight gain
steroids
BBs
insulin, SUs, meglitinides, TZDs
APs (clozapine, olanzapine, risp, quet)
gabapentin, pregabalin
TCAs
VPA
MAO-i
hormones
SSRIs
__________________
hypothyroidism
what drugs/conditions cause weight loss
topiramate
GLP-1s
SGLT2-i
bupropion
amphetamines
__________________
lupus
CF
celiacs
GERD
PUD
hyperthyroidism
TB
what OTC supplements are there for weight loss? are these recommended
bitter orange
caffeine
Alli (orlistat)
what qualifies a patient to receive a weight loss medication
BMI 30+ or
BMI 27+ with a weight-related condition (HLD, HTN, DM)
meds are always in addition to _________
lifestyle
what is the role of oral meds for weight loss
kick start
usually not for extended periods of time
what is the target weight loss for a patient on a weight loss med
5+% weight loss in 12 weeks
what is in Qsymia
phentermine/topiramate ER
Qsymia (phentermine/topiramate ER) is CI in
pregnancy, glaucoma, hyperthyroid, MAO-i
what are possible SE of Qsymia?
SATA
A. tachycardia
B. hypotension
C. depression
D. anxiety
E. psych disturbances
F. HA
G. vision changes
A. tachycardia
C. depression
D. anxiety
F. HA
G. vision changes
causes hypERtension
how should Qsymia be discontinued
with a taper
contains topamax and can increase seizure risk with abrupt d/c
which weight loss treatment has a REMS program
Qsymia (phentermine/topiramate ER)
Contrave containe
naltrexone/bupropion
Contrave is not approved for
MDD or psych dx
Contrave is CI in
kids, seizure disorder, opioid use, bulimia/anorexia, MAO-i, uncontrolled HTN
what are the GLP-1s approved for weight loss (brand and generic)?
saxenda (liraglutide)
Wegovy (semaglutide)
saxenda dosing
0.6mg SQ once daily
increase daily dose by 0.6mg once weekly to a target dose of
3mg SQ daily
wegovy dosing
0.25mg SQ weekly x4 weeks
titrate q4weeks to a target dose of 2.4mg SQ weekly
what are concerns with GLP-1 RAs
CI PMH or FH of medullary thyroid carcinoma or MEN2 syndrome
can cause pancreatitis, gastroparesis, hypoglycemia, nausea
may need to lower dose of insulins, SUs, meglitnides!
what are the brand names for orlistat
Alli = OTC
Xenical = Rx
orlistat MOA
decreases dietary fat absorption by ~30%
warnings for orlistat
liver damage
cholelithiasis
separate ADEK by 2+ hrs
max of 30% of kcals can be from fats
phentermine brand name
Adipex-P
phentermine dosing and duration
7.5-37.5mg PO QD x</= 12 weeks
what conditions are CI for phentermine
CVD, pregnancy, glaucoma, hx drug abuse, MAO-i, hyperthyroidism
who qualifies for bariatric surgery
BMI 40+
BMI 35+ + 1 obesity related condition
bariatric surgery can cause deficiencies in
ADEK
Ca
B12
iron
