Drug Allergies and ADR Flashcards
type A reactions
dose dependent
predictable
AGs and nephrotoxicity
doxazosin and orthostasis
Type B reactions
non dose-dep
unrelated to pharmacologic actions of drug and usually 2/2 pt specific factors
HLA allele
vancomycin and infusion rxn
G6PD deficiency
Type I HSR
immediate - 60 min
anaphylaxis
Ig-E mediated
bronchospasm, urticaria, angioedema
Type II HSR
delayed - within 5-8d
Ab-mediated
hemolytic anemia
thrombocytopenia
Type III HSR
delayed - 1+ week
immune complex mediated
serum sickness
Type IV HSR
delayed - 48h to weeks
T cell-mediated
SJS/TEN
what drugs can cause photosensitivity? Is this an intolerance or allergy?
intolerance
loops
thiazides
SMX/TMP
amiodarone
TTC
retinoids
SJ Wort
MTX
NSAIDs
1st gen AHs
tacro
what is TTP? what drugs can cause this?
thrombotic thrombocytopenic purpura
clots form throughout body which consumes plts resulting in bruises that leak throughout skin (purpura)
SMX/TMP and P2Y12-i
common drugs that cause SJS/TEN
lamotrigine
phenytoin
SMX/TMP
vancomycin
carbamazepine
oxcarbazepine
allopurinol
sulfasalazine
amiodarone
adult epi pen dose
0.3mg
pediatric epi pen dose and weight range
0.125mg for 15-30kg kids
what is the concentration of EN in all epi pens
1mg/mL
common treatments for anaphylaxis
EN
steroids
benadryl
IV fluids
sulfonamide allergy cross reacts with
loops
thiazides
SUs
zonisamide
celecoxib
acetazolamide
a sulfonamide and sulfite/sulfate allergy are cross reactive T or F
false
