Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

NAPLEX Prep > HIV > Flashcards

HIV Flashcards

1
Q

Dolutegravir

A

Tivicay

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Tivicay

A

Dolutegravir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dolutegravir/lamivudine

A

Dovato

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Dovato

A

doluteg/lamivudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

dolutegravir/lamivudine/abacavir

A

triumeq

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

triumeq

A

dolutegravir/lamivudine/abacavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

dolutegravir/emt/TAF

A

Biktarvy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

biktarvy

A

dolut/emt/TAF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

emt/TDF

A

Truvada

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

truvada

A

emt/TDF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

emt/TDF

A

truvada

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

descovy

A

emt/TAF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

emt/TAF

A

descovy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

rilpivirine/emt/TDF

A

Complera *w food

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Complera *w food

A

rilpivirine/emt/TDF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

rilpivirine/emt/TAF

A

odefesy *w food

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

odefesy

A

rilpivirine/emt/TAF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

abacavir/lamivudine

A

Epzicom

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the types of based ART regimens that are COMPLETE regimens

A

INSTI based
NNRTI based
PI based

20
Q

NRTIs
pneumonic for drugs
ADE of all
Pearls

A

LATTE
Lamivudine (LAM)
Abacavir
TDF
TAF
Emtracitibine

ADE all: lactic acidosis, hepatomegaly with steatosis, NVD, HA, inc LFTs

BBW: SCREEN ALL PATIENTS FOR HEP C AND HEP B FIRST
ABACAVIR: Screen for HLA-B*5701 allele

21
Q

Lamivudine
Brand name
MOA
in which regimens

A

Epivir
NRTI
in QD and BID regimens

22
Q

Abacavir
MOA
What is special about abacavir

A

NRTI
Screen for HLA-B*5701 allele
BBW for hypersensitivity rxn, if occurs patient must carry card saying abacavir HSRxn

23
Q

Emtracitibine
MOA
ADE

A

NRTI
hyperpigmentation of palms and soles of feet

24
Q

TDF and TAF
adverse effects of each

A

TDF (D for Dumpy)
- renal impairment, acute renal failure and fanconi
- dec dose in renal imp (CI CrCl <50)
- must avoid nephrotoxins (NSAIDS, AGs)
- dec MBD: dexa scans, CA and Vit D!

TAF
- hyperlipidemia

these ADE are not mutually exclusive, are just more predominant in one or other

25
Q

NNRTIs “-virine”
pneumonic for drugs
what regimens are these part of

A

REDEN
Rilpivirine
Efavirenz
Doravirine
Etavirine
Neviripine

NNRTI-based regimens with NNRTI +2NRTIs

26
Q

why are there no NRTI based regimens

A

NRTIs have low barrier to resistance

27
Q

rilpivirine
MOA
regimens part of
Pearls

A

NNRTI
NNRTI-based regimens with 2 NRTIs
RPV/EMT/TDF = Complera
RPV/EMT/TAF = Odefesy

take with FOOD and WATER (NO PROTEIN DRINKS)
CI with PPI, H2RA, antacids
Do not use if viral load >100,000 or CD4 <200 (high failure rate)
ADE: depression, inc SCr

28
Q

efavirenz
MOA
regimens part of
Pearls

A

NNRTI
Part of NNRTI-based regimens Atripla (D/C’d) and Symfilo (EFA/LAM/TDF)
take on EMPTY STOMACH qhs
ADE: CNS tox (sleep) so take at night, food would inc F but inc CNS tox
depression, suicidal thoughts

29
Q

INSTIs
drugs
ADE

A

dolutegravir, cabotegravir, elvitegravir, raltegravir
ADE: HA, insomnia, D, weight gain, depression, suicidal ideation
exacerbation of preexisting psych conditions

30
Q

Protease inhibitors (-navir)
ADE all
DDI/do not use with

A

ADE: inc LDL, inc TG, inc body fat, inc BG, insulin resistance. abdominal adiposity –> metabolic syndrome
inc LFTs, hepatitis
SJS/TEN, angioedema, bronchospasm
D/N
inc CVD risk
ALL ARE 3A4 SUBSTRATES AND INHIBITORS
DDI/do not use with
alfuzosin
colchicine
dronaderone
lovastatin, simvastatin
3A4 inducers (carbamazepine, penobarbital, rifampin, SJ Wort, phenytoin)
DOACs, ticagrelor
Hep C antivirals
hormonal contraceptives
steroids

31
Q

atazanavir
MOA
ADE
Pearls

A

PI
hyperbilirubinemia
needs ACDIC gut
take atazanavir 2 hours before or 1 hour after for tums and 10 hours after for H2RA

32
Q

which PIs should be used with caution in sulfa allergy

A

darunavir, tipranavir, fosamprenavir

33
Q

ritonavir DDI specific

A

ritonavir solution contains 43% alcohol –> avoid with metronidazole 2/2 disulfiram reaction

34
Q

why is ritonavir used as booster and not a PI

A

doses needed for ART are too high to tolerate and lower doses are used for boosting others

35
Q

cobicistat
MOA

A

booster, inhibits 3A4

36
Q

are boosters (rilpivirine and cobicistat) taken with or without food?

A

with food

37
Q

Miraviroc
MOA
pearls

A

CCR5 inhibitor
need tropism test beforehand to ensure HIV strain uses CCR5 or else ineffective (CXCR4/CCR5 mixed does not qualify)
CI CrCl <30 or use with 3A4 inducers or inhibitors

38
Q

fostemsavir
MOA
when to use

A

attachment inhibitor

used with other ARV in patients who are treatment experienced and not responding to current therapy

39
Q

ibalizumab-uiyk (Troganzo IV)

A

post-attachment inhibitor

used with other ARV in patients who are treatment experienced and not responding to current therapy

40
Q

enfuvirtide (Fuzeon)
MOA
ADE

A

fusion inhibitor

ADE: bacterial PNA, HSRxn, inj site reaction

41
Q

opportunistic infections possible in AIDS

A

MAC (mycobacterium avium complex)
pneumocystis jirovecii pneumo (PCP)
cryptococcus neoformans
histoplasmosis
severe candida infections (thrush, TB)

42
Q

Cancer thats common in AIDS

A

Kaposi’s sarcoma

43
Q

HIV wasting syndrome s/sx and tx options

A

dec appetite
dec body fat
dec muscle mass

dronabinol, megestrol inc appetite

44
Q

HIV in pregnancy

if on tx vs tx naive

A

continue current treatment

if naive, INSTI-based regimens with 2 NRTIs preferred (Biktarvy, Triumeq, Striblid, Genvoya)

CANNOT BREASTFEED

45
Q

PrEP
when given
meds preferred

A

before high risk activity

Truvada (EMT/TDF)
Descovy (EMT/TAF)

46
Q

PEP
when given
preferred meds
monitoring

A

within 72 hours after high risk activity
Raltegravir (Isentress) or Dolutegravir (Tivicay) PLUS Truvada

get baseline HIV Ab, repeat at 4-6 weeks, 3 months, 6 months

NAPLEX Prep (57 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions