Parkinson's Disease Flashcards
drugs that worsen PD
phenothiazines (prochorperazine)
metoclopramide
antipsychotics
of the antipsychotics, which has the lowest risk of worsening parkinsons disease
quetiapine
what are the preferred depression treatments in PD
SSRI
SNRI
Sinemet
contents
MOA
dosing
carbidopa/levodopa
levodopa is a DA precursor
carbidopa prevents levodopa breakdown in the periphery
IR start at 25/100mg PO TID
ER start at 50/200mg BID
adverse effects of sinemet
psychosis, hallucinations
somnolence, dizziness, nausea
orthostasis
brown/black bodily fluids
how many mg of carbidopa is required per day to inhibit dopa decarboxylase
70-100mg / day
Sinemet CI
MAO-i
includes phenelzine and isocarboxazid
___________ can be added to sinemet to prevent breakdown of levodopa via inhibiting COMT
entacapone
entacapone
role in therapy
dose
addition to sinemet, never monotherapy
200mg PO with each dose of levodopa
MDD 1600mg
DA agonists used in parkinsons
rotigotine patch (Neupro)
pramipexole (Mirapex)
ropinirole (Requip)
what is the injectable or SL DA agonist that can be used as rescue during “off periods”
Apomorphine (Apokyn)
amantadine
MOA
use
blocks DA breakdown
used for dyskinesias associated with peak-dose of carbidopa/levodopa
what medications inhibit MAO-B to treat PD
selegiline and rasagiline
selegiline and rasagiline are CI with
MAO-i (includes linezolid)
SSRI
SNRI
TCAs
opioids
what is used to treat tremor
benztropine
